Differences in the expression of restricted repetitive behaviors in female BTBR T  + tf/J mice.

Differences in the expression of restricted repetitive behaviors in female BTBR T + tf/J mice. Behav Brain Res. 2019 Jun 15;:112028 Authors: Amodeo DA, Pahua AE, Zarate M, Taylor JA, Peterson S, Posadas R, Oliver BL, Amodeo LR Abstract Autism spectrum disorder (ASD) is characterized by the expression of restricted repetitive behaviors (RRBs) and impairments in social recognition and communication. Epidemiological studies demonstrate males are three times more likely than females to be affected. Although this is the case, more recent studies suggest females may be underrepresented in these numbers due to standard clinical measures of RRBs and social behaviors. In addition, many studies examining mouse models of ASD exclude females due to the sex disparity in diagnoses. The present study examined how female and male BTBR T + Itpr3tf /J (BTBR) compare to control C57BL/6 J mice on tests of RRBs (probabilistic reversal learning, repetitive grooming, spontaneous alternation, and marble burying) and social behaviors (three chambered social approach task). Utilizing a spatial reversal learning test with 80/20 probabilistic feedback, in which ASD individuals have exhibited deficits, we find that female BTBR mice do not show the same impairment we found in male BTBR mice. Interestingly, control female C57BL/6 J mice required more trials to reach criterion. Female BTBR mice expressed comparable rates of repetitive grooming,...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Conclusion: Genetic factors primarily contribute to structural variation in subcortical CSC regions, regardless of ASD, but environmental factors may exert a greater influence on the development of grey matter thickness in the OFC and ACC in children with ASD. The increased vulnerability of OFC grey matter to environmental influences may also mediate some heterogeneity in RRB severity in children with ASD. PMID: 31603639 [PubMed - as supplied by publisher]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research
Publication date: Available online 12 October 2019Source: Computers in Human BehaviorAuthor(s): Vishav Jyoti, Uttama LahiriAbstractOne of the important facets of effective social communication is Joint Attention (JA). However, children with Autism Spectrum Disorder (ASD) are often characterized by JA-related deficits, adversely affecting their social communication. In conventional interventions, therapists use different types of JA cues depending on one's capability to pick up the delivered cue. Though effective, conventional approaches suffer from restricted healthcare resources, cost, etc. With an increase in computation...
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Source Type: research
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Source: Trends in Neuroscience and Education - Category: Neuroscience Source Type: research
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Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
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In this study, we investigated the effects of VGX-1027 on self-grooming, marble burying and sociability tests using BTBR mice. We further examined its effect on IL-1β, IL-6, IL-10, TNF-α, IFN-γ, and NF-κB p65 production in splenic CD4+ cells and on IL-1β, IL-6, IL-10, TNF-α, IFN-γ, COX-2, and iNOS (NOS2) protein and mRNA expression in brain tissues. The administration of VGX-1027 was found to attenuate self-grooming and marble burying behaviors, and enhance social interactions in BTBR mice. Additionally, VGX-1027 treatment resulted in a substantial decrease in IL-1β, IL-6, TNF-&...
Source: Life Sciences - Category: Biology Source Type: research
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