Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats.

Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats. Behav Brain Res. 2019 Jun 15;372:112023 Authors: Papadakakis A, Sidiropoulou K, Panagis G Abstract Epidemiological and clinical studies suggest that early-life stress (ELS) may lead to the development of mental disorders in adulthood. Maternal separation (MS) is a valid animal model of ELS that produces detrimental effects on brain and behavior of experimental animals. Positive environmental stimuli have been shown to counteract the behavioral deficits of ELS and enhance neuroplasticity. Recent data indicate that music may serve as a form of environmental enrichment in experimental animals. However, the underlying mechanisms through which musical enrichment exerts its effects are poorly understood. Male Sprague-Dawley rats were submitted to a 3 h MS protocol during postnatal days (PND) 2-14, while another group was left undisturbed. Half of the animals within each group were exposed from PND 21 to PND 76 for 12 h/day to Mozart K. 448. At approximately three months of age, elevated plus maze procedure, forced swim test and social approach task were applied to test whether music exposure can mitigate the effects of MS stress on animal emotional behaviors. Moreover, we investigated the effects of these treatments on dendritic spine density in the CA1 region of hippocampus. As expected, MS rats showed decreased sociability, increased anx...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Maternal prenatal depressive or anxiety symptoms are associated with adverse maternal and infant health outcomes. With prevalence rates of maternal prenatal depression and anxiety ranging between 10 and 20%, a...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Conditions:   Pregnancy Related;   Stress, Psychological;   Anxiety;   Perinatal Depression Interventions:   Behavioral: SMART Pregnancy;   Behavioral: Treatment as usual Sponsors:   Stony Brook University;   Massachusetts General Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPrenatal maternal depression is associated with developmental disorders in offspring. However, the specific effects of the intensity of prenatal depressive symptoms on infant behavior remain poorly explored. The aim of this work is to explore the links between early neonatal behavior and maternal prenatal depressive symptoms, independently from maternal pre- and postnatal anxiety and early postnatal maternal depressive symptoms. Five hundred and ninety-eight women and their newborns from the MATQUID cohort were prospectively evaluated during the 8th month of pregnancy (T1) and at day 3 postpartum (T2). We analyzed ...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Conditions:   Depression, Postpartum;   Anxiety Intervention:   Behavioral: Therapist-assisted ICBT Sponsor:   University of Regina Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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