Impact of Socioeconomic Status on Outcomes of Patients with Kawasaki Disease
To evaluate the association of neighborhood socioeconomic status (SES) with time to intravenous immunoglobulin treatment, length of stay (LOS), and coronary artery aneurysms (CAAs) in patients with Kawasaki disease.
Conclusions: Our results suggest that insufficient control of monocyte suppression and T-cell activation, especially in terms of the CD8-related immune system, are associated with IVIG resistance. The restoration of T-cell suppression may be important for KD recovery. These findings provide insight into the mechanism of IVIG resistance. PMID: 31272272 [PubMed - as supplied by publisher]
Kawasaki disease (KD) is a systemic vasculitis which may be associated with coronary artery aneurysms. A notable risk factor for the development of coronary artery aneurysms is resistance to intravenous immuno...
The objective of this study was to determine the existence and magnitude of any increased risk of Kawasaki disease in the 28 days following PCV13 vaccination. Methods and findingsThe study population included mostly commercially insured children from birth to
Condition: Kawasaki Disease Interventions: Drug: Immunoglobulin G; Drug: Acetylsalicylic acid Sponsor: Green Cross Corporation Active, not recruiting
PMID: 31261206 [PubMed - as supplied by publisher]
PMID: 31242500 [PubMed - as supplied by publisher]
Hamada H, Suzuki H, Onouchi Y, Ebata R, Terai M, Fuse S, et al. Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): A randomized controlled, open-label blinded endpoints, phase 3 trial. Lancet 2019;393:1128-37.
Authors: Yoon KL PMID: 31208167 [PubMed - as supplied by publisher]