More Gluten In New Wheat Probably Not Responsible For Increase In Celiac Disease

No clear evidence exists to support the idea that celiac disease is increasing in prevalence because farmers are growing strains of wheat that contain more gluten. That's the conclusion of an article in the ACS' Journal of Agricultural and Food Chemistry. Donald D. Kasarda cites evidence that the incidence of celiac disease increased during the second half of the 20th century. Some estimates indicate that the disease is 4 times more common today...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Food Intolerance Source Type: news

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Introduction: Celiac disease (CD) is a widespread enteropathy triggered by a diet containing cereals with gliadins in genetically predisposed individuals. Alpha-gliadin peptide 31 –43 (p31-43) is considered the main responsible of the innate immune response in CD patients and type 2 transglutaminase (TG2) enzyme is involved in CD by enhancing gliadin immunogenicity. Evidence has been reported on a role of TG2 in modulate p31-43 uptake by intestinal cells; indeed, antibodies to TG2 specifically reduced both p31-43 uptake by cells and its biological activity.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
This study retrospectively reviewed 20 consecutive patients who underwent DP-CAR at a single institution.ResultsEleven of 20 patients (55.0%) received NAC. Their first regimens were gemcitabine (GEM) plus nab-PTX (n = 7, 63.6%), GEM plus S-1 (n = 3, 27.3%), and GEM (n = 1, 9.1%). Although two patients converted to a second regimen, none abandoned NAC due to adverse effects or could not undergo a planned procedure for disease progression. There were no significant differences in intraoperative variables, morbidity, including pancreatic fistula and delayed gas tric emptying, and mort...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Conditions:   Celiac Disease;   Ovarian Failure Intervention:   Other: Group A Sponsor:   Bakirkoy Dr. Sadi Konuk Research and Training Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewCeliac disease (CD) is an autoimmune enteropathy triggered by gluten. The purpose of this review is to examine the major genetic and environmental factors that contribute to CD pathogenesis.Recent FindingsWe reviewed the current state of knowledge on the genetic and environmental components that play a role in CD onset. A genome-wide association study (GWAS) analysis has highlighted several genes other than HLA involved in CD. Recent studies have shown that HLA haplotype influences the microbiome composition in infants and that dysbiosis in the intestinal microflora, in turn, contributes to loss of...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Publication date: 30 November 2019Source: Food Chemistry, Volume 299Author(s): Samira Dakhili, Leyla Abdolalizadeh, Seyede Marzieh Hosseini, Saeedeh Shojaee-Aliabadi, Leila MirmoghtadaieAbstractQuinoa (Chenopodium quinoa willd.) is an annual herbaceous flowering plant showing appropriate nutritional and functional properties due to its high quality protein with a wide amino acid spectrum, particularly rich in lysine. The mature quinoa seed predominantly consists of 11S-type globulin called chenopodin, comprising about 37% of the total protein, and also 2S albumin accounting for 35% of the seed protein both stabilized throu...
Source: Food Chemistry - Category: Food Science Source Type: research
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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Condition:   Celiac Disease in Children Interventions:   Diagnostic Test: anti-tissue transglutaminase group;   Diagnostic Test: biopsy group Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Is measurement of gluten immunogenic peptides in stool useful as a marker of gluten-free diet adherence in children newly diagnosed with celiac disease?Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Abstract Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scena...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
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