Prevent bone loss from osteoporosis with capillary wormwood

(Natural News) Researchers found a new medicinal plant that can be used to support bone health. A study published in The American Journal of Chinese Medicine found that capillary wormwood (Artemisia capillaris) can help prevent bone loss by regulating osteoblast mineralization, osteoclast formation, and bone resorption. In the study, researchers from Korea Institute of Oriental Medicine...
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AbstractPurpose of ReviewThe molecular mechanisms of the bone disease associated with chronic kidney disease (CKD), called renal osteodystrophy (ROD), are poorly understood. New transcriptomics technologies may provide clinically relevant insights into the pathogenesis of ROD. This review summarizes current progress and limitations in the study and treatment of ROD, and in transcriptomics analyses of skeletal tissues.Recent FindingsROD is characterized by poor bone quality and strength leading to increased risk of fracture. Recent studies indicate permanent alterations in bone cell populations during ROD. Single-cell trans...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewHyperparathyroidism may be due to an autonomous hypersecretion of parathyroid hormone (PTH) or occurs in response to a number of physiological stimuli. A number of recent findings have provided new insights into the importance of the calcium-parathyroid-vitamin D axis to bone in normal physiology and pathological conditions.Recent FindingsPTH is known to affect bone microarchitecture with different effects on cortical and trabecular bone compartments. In trabecular bone, PTH may exert anabolic effects, whereas PTH promotes bone resorption in cortical bone. Vertebral fractures are prevalent in prima...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Asiatic acid is a triterpenoid compound extracted from a medicinal plant Centella asiatica. It has been used as a highly efficient compound for the treatment of cancer and hyperlipidemia, as well as possessing potential antiinflammatory properties. However, its effects on bone metabolism and osteoporosis haven’t been reported. The purpose of our research were to reveal the biomolecular effects of asiatic acid on osteoclasts, and its underlying molecular mechanisms regulating its effects on receptor activator of NF-κB ligand (RANKL)-induced signaling pathways. We found that asiatic acid inhibited multinucleated ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00439A, CommunicationKonstantinos D. Demadis, Daphne Chandrinou, Duane Choquesillo-Lazarte, Kostas Papathanasiou, Petri Turhanen, Maria Vassaki, Chrystalleni Hadjicharalambous In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions (eg. Ca2+ and Mg2+) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
TGF-β1 polymorphism in postmenopausal osteoporosis. Panminerva Med. 2020 Mar 23;: Authors: Zhong L, Fu H, Song Y, Li H, Xu Q, Jia X PMID: 32208410 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Conclusion: Muscle strength as measured by grip strength and knee extension was statistically significantly correlated with the WOMAC scores in patients with knee symptoms regardless of whether radiologic signs of knee osteoarthritis were observed.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionDegraded microarchitecture by TBS was associated with prevalent vertebral fractures in SLE patients. Our result suggests that TBS can be a complementary tool for assessing vertebral fracture prevalence in this population.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
AbstractBackground Population screening for osteoporosis using bone mineral density scan is not feasible in Malaysia as this test is costly. Hence, there is a need to develop a more efficient method to screen for osteoporosis.Objectives To determine the feasibility of an interprofessional collaborative osteoporosis screening programme (IPC-OSP).Methods Postmenopausal women aged  ≥ 50 years, who had not been diagnosed with osteoporosis were recruited from a primary care clinic from June to August 2014. Patients were assessed for their osteoporosis risk and were counselled on prevention methods. Patient...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Osteolytic bone disease is characterized by excessive osteoclast bone resorption leading to increased skeletal fragility and fracture risk. Multinucleated osteoclasts formed through the fusion of mononuclear precursors are the principle cell capable of bone resorption. Pregnenolone (Preg) is the grand precursor of most if not all steroid hormones and have been suggested to be a novel anti-osteoporotic agent. However, the effects of Preg on osteoclast biology and function has yet to be shown. Here we examined the effect of Preg on receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast formation and b...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Osteoporosis is a complex disease with a strong genetic contribution. A recently published genome-wide association study (GWAS) for estimated bone mineral density (eBMD) identified 1103 independent genome-wide...
Source: Genome Biology - Category: Genetics & Stem Cells Authors: Tags: Research Source Type: research
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