Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections

Emergence and re-emergence of respiratory virus infections represent a significant threat to global public health, as they occur seasonally and less frequently (such in the case of influenza virus) as pandemic infections. Some of these viruses have been in the human population for centuries and others had recently emerged as a public health problem. Influenza viruses have been affecting the human population for a long time now; however, their ability to rapidly evolve through antigenic drift and antigenic shift causes the emergence of new strains. A recent example of these events is the avian-origin H7N9 influenza virus outbreak currently undergoing in China. Human H7N9 influenza viruses are resistant to amantidines and some strains are also resistant to neuraminidase inhibitors greatly limiting the options for treatment. Respiratory syncytial virus (RSV) may cause a lower respiratory tract infection characterized by bronchiolitis and pneumonia mainly in children and the elderly. Infection with RSV can cause severe disease and even death, imposing a severe burden for pediatric and geriatric health systems worldwide. Treatment for RSV is mainly supportive since the only approved therapy, a monoclonal antibody, is recommended for prophylactic use in high risk patients. The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging respiratory virus. The virus was first recognized in 2012 and it is associated with a lower respiratory tract disease that is more s...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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We report a case of a 46-year-old Chinese male who presented with six months history of abdominal pain, weight loss and rectal bleeding. Diagnostic colonoscopy revealed multiple aphthous ulcers within the ileo-caecal region and distal transverse colon, separated by normal mucosa, mimicking skip lesions of Crohn's colitis. Computer topography (CT) scan of the abdomen showed multiple circumferential thickenings involving predominantly the right colon. A clinical diagnosis of colonic Crohn's disease with possible perforation was made. An extended right hemicolectomy was performed due to uncontrolled rectal bleeding. Histopath...
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
OBJECTIVE From the global views to analyze the status and trends of injury burden in China,to provide reference for injury prevention and control decision-making in China. METHODS Using the data of the GBD 2017,compared and analyzed the injury burd...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
This article evalua...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
The last decade witnessed a rapid growth in the number of powered two wheelers (PTWs) on Chinese roads. PTWs offer a convenient, flexible, and affordable mobility solution. They are also considered as an environment-friendly alternative to automobiles. Des...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
ConclusionsFour weeks nutritional quality education improved the understanding of dietary nutrition among Chinese elite male young soccer players.
Source: Journal of Exercise Science and Fitness - Category: Sports Medicine Source Type: research
Publication date: November 2019Source: Journal of Experimental Social Psychology, Volume 85Author(s): Duo Jiang, Dolores AlbarracínAbstractHuman awareness of the passing of time leads to psychological processes designed to handle these inherent temporal limitations. Deadlines serve to energize desired courses of action and are likely to exert effects by leveraging general goals. Movement (e.g., walking, running) and stasis (e.g., standing, sitting), for example, may elicit general action and inaction goals that affect unrelated, time-constrained decisions. Across one field experiment and three lab experiments, prior...
Source: Journal of Experimental Social Psychology - Category: Psychiatry & Psychology Source Type: research
This article highlights practical considerations to help clinicians appropriately apply the most recent vaccine recommendations to their patients.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: IMMUNIZATIONS Source Type: research
The high — and rising — rate of nonmedical vaccine exemptions has left major metropolitan areas vulnerable to measles outbreaks; other states have similar pockets of undervaccinated schoolchildren.Medscape Medical News
Source: Medscape ObGyn and Womens Health Headlines - Category: OBGYN Tags: Infectious Diseases News Source Type: news
Abstract With the development of anesthesiology, patient safety has been remarkably improved, but the postoperative mortality rate at 30 days is still as high as 0.56%-4%, and the morbidity is even higher. Three years ago, the Chinese Society of Anesthesiology proposed that the direction of the anesthesiology development should be changed to perioperative medicine in China. Anesthesiologists should pay more attention to the long-term outcome. In this article, we introduced what we have done, what the challenges are, and what we should do in the future with regard to the practice of perioperative medicine in China....
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
The U.S. Department of Health and Human Services (HHS) said on Wednesday it will fund the manufacturing of Merck&Co Inc's investigational Ebola vaccine called V920, in response to the outbreak of the deadly virus in the Democratic Republic of the Congo (DRC).
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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