The carnitine-butyrobetaine-TMAO pathway after cardiac transplant Impact on cardiac allograft vasculopathy and acute rejection

Alterations in the partly microbiota-dependent carnitine-butyrobetaine ( γBB)- trimethylamine-N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated if circulating γBB, TMAO and their common precursors carnitine and trimethyllysine (TML) were dysregulated after heart transplantation and associated with deve lopment of cardiac allograft vasculopathy (CAV) and acute rejection.

Source: The Journal of Heart and Lung Transplantation - June 18, 2019 Category: Transplant Surgery Authors: Marius Tr øseid, Cristiane C.K. Mayerhofer, Kaspar Broch, Satish Arora, Asbjørn Svardal, Johannes R. Hov, Arne K. Andreassen, Einar Gude, Kristjan Karason, Gøran Dellgren, Rolf K. Berge, Lars Gullestad, Pål Aukrust, Thor Ueland Tags: Original Clinical Science Source Type: research