Icam-1 promotes the abnormal endothelial cell phenotype in chronic thromboembolic pulmonary hypertension
These findings bring new insight into the role of endothelial cells in the pathogenesis of CTEPH, highlighting the role of endothelial ICAM-1. We provide the first in vitro demonstration that ECs isolated from organized thrombus of CTEPH patients exhibit dysfunctional phenotype. Furthermore, our findings demonstrate that ICAM-1 overproduction by ECs induces a hyperproliferative and apoptosis-resistant EC phenotype via an autocrine loop. The KE and EE genotypes are more frequent in patients with CTEPH than controls but are not associated with disease severity, suggesting that ICAM-1 E469K polymorphism may play a role in the pathogenesis of CTEPH.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Jennifer Arthur Ataam, Olaf Mercier, Lilia Lamrani, Myriam Amsallem, Joanna Arthur Ataam, Stephanie Arthur Ataam, Julien Guihaire, Florence Lecerf, V éronique Capuano, Maria Rosa Ghigna, François Haddad, Elie Fadel, Saadia Eddahibi Tags: Original Clinical Science Source Type: research
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