Gold and silver bio/nano-hybrids-based electrochemical immunosensor for ultrasensitive detection of carcinoembryonic antigen

Publication date: Available online 19 June 2019Source: Biosensors and BioelectronicsAuthor(s): Sattar Akbari Nakhjavani, Hadi Afsharan, Balal Khalilzadeh, Mohammad Hossein Ghahremani, Sandro Carrara, Yadollah OmidiAbstractCarcinoembryonic antigen (CEA) is an important oncomarker for the detection of breast cancer. For ultra-sensitive sensing of CEA with great specificity and accuracy, an innovative and reliable electrochemical immunosensor was developed using various nano-hybrids. A glassy carbon electrode (GC) was modified with thiolated graphene oxide (T-GO) to elevate the active surface area of the electrode. The streptavidin-coated gold nanoparticles (AuNPs) were used to increase the conductivity of the sensing area as well as the loading capacity of the biotinylated monoclonal antibody (mAb). A sandwich-on approach was developed to reach a low limit of detection (LOD). The biotinylated mAb, streptavidin coated silver nanoparticles (AgNPs) and horseradish peroxidase (HRP), altogether, formed the signaling probe of the proposed immunosensor. The electrochemical signal was significantly enhanced in the presence of hydroquinone (HQ) and hydrogen peroxide (H2O2). Under the optimized conditions, the proposed immunosensor presented an excellent performance in a linear range of 100 fg/mL to 5 pg/mL with a low detection limit of 75 fg/mL. The engineered immunosensor displayed excellent specificity for the detection of CEA even in the real human serum, upon which it is propo...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research

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Publication date: Available online 15 July 2019Source: Journal of Molecular StructureAuthor(s): Mousa Al-Noaimi, Firas F. Awwadi, Wamidh H. Talib, Salem Atia, Hassan H. HammudAbstractPalladium(II) complex [Pd(HL)Cl] (1) (H2L = 2-PhS(C6H4)NH-NC=(COCH3)–NHC6H5) has been synthesized by reacting K2PdCl4 with H2L. The pincer H2L ligand is coordinated to a Pd(II) in an anionic 5π electron form via k3 –SNN to produce neutral 1-trans and 1-cis isomers in the solid state. The structures of two isomers (1-trans and 1-cis) were determined by single crystal X-ray diffraction. Furthermore, complex 1 has been characte...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
ConclusionVinorelbine pharmacokinetics were found to be comparable between Asian and European patients. No relevant influence of ethnicity on vinorelbine bioavailability and clearance for oral and intravenous routes of administration was observed.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
The automated breast volume scanner (ABVS) performs just as well as handheld...Read more on AuntMinnie.comRelated Reading: Handheld ultrasound market poised for next wave of growth ABUS better than DBT for diagnostic workup DBT plus ABVS offers a breast cancer staging alternative ARRS: ABVS ups cancer detection in Asian women Automated breast US improves breast cancer detection
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(Johns Hopkins University) A new reusable device created by the Johns Hopkins University can help women with breast cancer in lower income countries by using carbon dioxide, a widely available and affordable gas, to power a cancer tissue-freezing probe instead of industry-standard argon.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Cell Death &Disease, Published online: 15 July 2019; doi:10.1038/s41419-019-1774-zThe Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
British Journal of Cancer, Published online: 15 July 2019; doi:10.1038/s41416-019-0520-8Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 13 July 2019Source: Seminars in Cancer BiologyAuthor(s): Zoi Piperigkou, Nikos K. KaramanosAbstractThe biological functions of estrogens are regulated by estrogen receptors (ERα and ERβ), which contribute in the progression of several hormone-responsive cancer types via estrogen signaling mechanisms. The coordinated actions of ERs and extracellular matrix (ECM) macromolecules are principal mediators of ECM remodeling in the tumor and the adjacent stroma. In breast cancer, ERs are critical biomarkers as their expression in breast tumor determines the disease-free survival, yet g...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Correction to "Enzymatic stimuli-responsive methotrexate-conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition". J Biomed Mater Res A. 2019 Sep;107(9):2115 Authors: PMID: 31301222 [PubMed - in process]
Source: Biomed Res - Category: Research Tags: J Biomed Mater Res A Source Type: research
(Natural News) Breast augmentation is the most common type of cosmetic surgery in the U.S., with more than 300,000 women getting breast implants a year. Most women usually get breast implants for aesthetic purposes, while the rest see it as an option following a breast cancer surgery. In a recent statement, however, the Food and Drug Administration...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
The internet is awash with ads for costly but bogus treatments – and claims that scientists are suppressing a cure for the diseaseFor Eileen O ’Sullivan, being diagnosed with breast cancer in 2013 was the catalyst for a deluge of distinctly unscientific and frequently dangerous advice. An investment manager with a analytical mind, she began seeking information to better understand her potentially life-altering condition. But from the mom ent Eileen starting searching online, misinformation was unavoidable: “This is when all the suggestions start rolling in,” she says. “Before diagnosis, I had ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Cancer Health Society Cancer research Medical research Internet Technology Facebook Social networking Media Crowdfunding Source Type: news
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