Molecules, Vol. 24, Pages 2277: Kaempferol: A Key Emphasis to Its Anticancer Potential

Molecules, Vol. 24, Pages 2277: Kaempferol: A Key Emphasis to Its Anticancer Potential Molecules doi: 10.3390/molecules24122277 Authors: Muhammad Imran Bahare Salehi Javad Sharifi-Rad Tanweer Aslam Gondal Farhan Saeed Ali Imran Muhammad Shahbaz Patrick Valere Tsouh Fokou Muhammad Umair Arshad Haroon Khan Susana G. Guerreiro Natália Martins Leticia M. Estevinho A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathwa...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research

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