Chronic kidney disease and fracture risk: a mechanistic insight

Whitlock et  al.1 showed that the Fracture Risk Assessment Tool, developed to predict fracture risk in the general population, was able to be used in patients with nondialysis chronic kidney disease (CKD) and highlighted that CKD could not be an independent risk factor for fractures. To support the authors’ suggestion, I here propose the key involvement of physical activity; CKD is inversely associated with physical activity.2,3 Major causes of osteoporotic fractures are skeletal fragility and minor trauma such as falls, both of which are significantly influenced by habitual physical activity.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research