Chronic kidney disease and fracture risk: a mechanistic insight

Whitlock et  al.1 showed that the Fracture Risk Assessment Tool, developed to predict fracture risk in the general population, was able to be used in patients with nondialysis chronic kidney disease (CKD) and highlighted that CKD could not be an independent risk factor for fractures. To support the authors’ suggestion, I here propose the key involvement of physical activity; CKD is inversely associated with physical activity.2,3 Major causes of osteoporotic fractures are skeletal fragility and minor trauma such as falls, both of which are significantly influenced by habitual physical activity.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research

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Authors: Chandra A Abstract Thyroid hormones are important for growth and maintenance of kidney functions. Hypothyroidism has significant health consequences. Subclinical hypothyroidism has been less well defined clinically. Prevalence among women increases with age especially those with thyroid antibodies. Subclinical hypothyroidism carries the risk of developing overt hypothyroidism, subsequent cardiovascular health risks and renal dysfunction. Continuous clinical monitoring is recommended to evaluate the therapeutic response and possible adverse effects of over treatment requiring dosage adjustment. The present ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
This study was performed to assess the effects of aerobic exercise training in adults with CKD.MethodsMEDLINE, EMBASE, CENTRAL, Web of Science were searched up to December 2018 to identify eligible randomized controlled trials (RCTs) that studied aerobic exercise in adults with CKD. Primary outcomes include oxygen consumption at peak exercise (VO2 peak), exercise capacity, blood pressure, heart rate, and health-related quality of life (HRQoL). Statistical analysis was performed using Review Manager 5.2.1 software.ResultsThirty-one trials, containing 1305 adults with CKD, were included. The most used aerobic exercise progra...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
AbstractObjectivesContrast-induced acute kidney injury (CI-AKI) is a serious complication in patients undergoing diagnostic cardiac angiography or percutaneous coronary intervention. We aimed to evaluate the preventive effects of left ventricular end-diastolic pressure (LVEDP)-guided hydration for the prevention of CI-AKI in patients with chronic kidney disease undergoing cardiac catheterization.MethodsThis prospective randomized single-blind clinical trial enrolled 114 eligible patients with an estimated glomerular filtration rate (eGFR) of 15  
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
AbstractPurpose of ReviewTo distinguish extreme and very high atherosclerotic cardiovascular disease (ASCVD) event risk based on prospective epidemiological studies and clinical trial results.Recent FindingsClinical practice guidelines have categorized patients with either a history of one or more “clinical ASCVD” events or “coronary heart disease (CHD) risk equivalency” to be at “very high risk” for a recurrence or a first event, respectively. A 20% or greater 10-year ASCVD risk for a composite 3-point “major” atherosclerotic cardiovascular event (MACE) of non-fatal myocardi...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Urinary creatinine excretion reflecting endogenous creatinine synthesis rate (CSR) is an established measure of muscle mass in the general populations and in patients with chronic kidney disease. There is increasing data to suggest that CSR not only reflects muscle mass, but also muscle function. In dialysis patients, CSR has rarely been studied since it requires dialysate collection. We aimed to study whether CSR is associated with muscle strength, and self-reported physical health in dialysis patients.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Letter to the Editor Source Type: research
Publication date: Available online 20 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Yas Sanaiha, Behdad Kavianpour, Peter Downey, Raveendra Morchi, Richard J. Shemin, Peyman BenharashAbstractBackgroundIn the current era of value based healthcare delivery, an understanding of patient populations at greatest risk for mortality, complications, and readmissions after Thoracic Endovascular Aortic Repair (TEVAR) is warranted. Thus, the present study aimed to evaluate outcomes after TEVAR for patients with varying degrees of renal dysfunction.MethodsAll patients who underwent TEVAR from 2010-2015 in the NRD were ident...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Gupta P, Gupta R, Gupta AK Abstract The chronic complications of Diabetes Mellitus (DM), which may be present in as many as 50% of the patients at the time of diagnosis, are a major burden for both individuals with the disease and health systems and it has been estimated that as much as 60-70% of healthcare expenditure related to diabetes (about 670 billion dollars a year) is currently attributable to chronic complications of the disease. These high prevalence rates are widely acknowledged to further rise as poor lifestyle choices and their consequences continue to rise. Adding to that is an aging populati...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionsRemission of type 2 diabetes 5 years after bariatric surgery was associated with improvements in albuminuria and stabilized prognostic risk for CKD, but not with eGFR. Lower kidney function and greater prognostic risk at the time of bariatric surgery was linked to a lower likelihood of diabetes remission. These results highlight the need to identify the mechanisms through which bariatric surgery may delay the long-term progression of CKD in type 2 diabetes.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: September 2019Source: IJC Heart &Vasculature, Volume 24Author(s): Ming-Yen Ng, Pui Min Yap, Kai Hang Yiu
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
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