Gut microbiome and kidney stone disease: not just an Oxalobacter story

Intestinal regulation of oxalate absorption is a complex mechanism, not exclusively reliant on the oxalate-degrading anaerobe Oxalobacter formigenes. Using metagenomics, Miller et  al. were able to describe a network of bacterial taxa co-occurring with Oxalobacter formigenes in fecal samples from non–stone forming controls and less represented in stone formers. These findings may help to illuminate why previous intervention studies with probiotics have failed to reduce the risk of hyperoxaluria, opening new possibilities for future research.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research

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AbstractA decision support system (DSS) was developed to predict postoperative outcome of a kidney stone treatment procedure, particularly percutaneous nephrolithotomy (PCNL). The system can serve as a promising tool to provide counseling before an operation. The overall procedure includes data collection and prediction model development. Pre/postoperative variables of 254 patients were collected. For feature vector, we used 26 variables from three categories including patient history variables, kidney stone parameters, and laboratory data. The prediction model was developed using machine learning techniques, which include...
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research
We thank Sheng-Wen Niu and colleagues1 for highlighting their intriguing data on the association between pioglitazone use and incident nephrolithiasis in patients with type 2 diabetes in the Taiwanese National Health Insurance Research Database. In their population-based retrospective analysis, pioglitazone users experienced a 26% reduction in kidney stone incidence compared with matched diabetic nonpioglitazone users, and greater risk reduction was observed with higher cumulative pioglitazone exposure.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Maalouf et  al.1 investigated the urinary biochemical effect of pioglitazone in patients with idiopathic uric acid nephrolithiasis. They showed that pioglitazone not only improved the metabolic syndrome, but also increased urine pH by reducing the acid load to the kidney, raising ammoniagenesis and ammonium e xcretion. However, the study size was small and whether pioglitazone will affect the incidence of nephrolithiasis in patients with the metabolic syndrome or diabetes or both is unknown. The interesting observation by Maalouf et al.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
A study to evaluate the prevalence of uric acid (UA) nephrolithiasis with dual-energy CT (DECT) and explore the risk factors for kidney stones in primary gout patients.
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
AbstractThere is controversy regarding the predicting value of preoperative urine culture for post-percutaneous nephrolithotripsy (PCNL) infection. The purpose of our study was to re-evaluate the importance of preoperative urine culture for developing post-PCNL systemic inflammatory response syndrome (SIRS) in China. A total of 303 patients undergone PCNL from March 2012 to January 2018 were recruited. Urine tests, urine cultures and the perioperative data were prospectively recorded and analyzed. 95 patients (31.4%) were identified with positive preoperative urine cultures. Female patients had significantly higher rate of...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
If you’ve been diagnosed with kidney stones (urolithiasis), you may have several options for treatment. These include medical therapy, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotripsy (PCNL), and ureteroscopy. A brief anatomy of the urinary tract The urinary tract includes kidneys (two organs that filter waste and extra water from the blood) ureters (two tubes bringing urine from each kidney to the bladder) bladder (organ that collects urine) urethra (a single tube through which urine in the bladder passes out of the body). The evaluation for kidney stones If your symptoms suggest kidney...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Kidney and urinary tract Men's Health Women's Health Source Type: blogs
AbstractObjectivesWe aimed to evaluate the role of nephrin and podocalyxin in determining the intervals between shock wave lithotripsy (SWL) sessions and how soon the kidney damage was recovered.MethodsThis work was a prospective study that included 30 patients with unilateral kidney stones. The patients ’ midflow urine samples were collected before SWL and 1 h, 1 day and 1 week after the procedure. Nephrin and podocalyxin levels in the urine samples were measured by the enzyme-linked immunosorbent assay method.ResultsAmong the 30 patients who underwent SWL, 19 were males and 11 were females. The mean ...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: Within the limits of a single-center study, our data quantify CKD as common in PE women and suggest the presence of a "CKD phenotype" characterised by preterm delivery and adequate growth, implying that CKD is compatible with good placental function up to the last phase of pregnancy. PMID: 31317437 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
AbstractStandard of care for large or complex renal stones is percutaneous nephrolithotomy. Robotic pyelolithotomy, however, may be a feasible alternative, but limited data exist on its outcomes and complications. Our study objective was to describe the outcomes and peri-operative complications of robotic pyelolithotomy for complex renal calculi. We performed a retrospective analysis of robotic pyelolithotomy at our tertiary academic institution from 2015 to 2018. Demographics, stone clearance rates, complications, estimated blood loss, operative time, and length of stay were reported. 15 patients were included with a medi...
Source: Journal of Robotic Surgery - Category: Surgery Source Type: research
Conditions:   Urolithiasis;   Calyx; Calculus Interventions:   Dietary Supplement: Potassium and magnesium citrate;   Dietary Supplement: Placebo Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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