Biologics in acute burn injury - Kogan S, Halsey J, Agag RL.

There have been significant advances in the care of burns over the past decade. As a result of the improved survival of burn patients, attention has shifted to the optimized management of their wounds. Traditionally, autografts have been described as the g...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Related Links:

There have been significant advances in the care of burns over the past decade. As a result of the improved survival of burn patients, attention has shifted to the optimized management of their wounds. Traditionally, autografts have been described as the gold standard treatment in cases of deep second- and third-degree burn wounds; however, they are limited especially in large surface area burns. As such, advancements have been made in the development of biologic dressings, which attempt to mimic the function of the lost epidermis and/or dermis. The ideal biologic dressing is nontoxic, lacks antigenicity, is immunologicall...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
Publication date: Available online 6 June 2019Source: BurnsAuthor(s): Clifford C. Sheckter, Jeremy Goverman
Source: Burns - Category: Dermatology Source Type: research
Publication date: Available online 5 June 2019Source: BurnsAuthor(s): Michel H.E. Hermans
Source: Burns - Category: Dermatology Source Type: research
The objective of this systematic review is to compare allograft skin with other skin substitutes, which have been used in the treatment of burns.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Review Source Type: research
The objective of this systematic review is to compare AS with other skin substitutes, which have been used in the treatment of burns.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Review Source Type: research
Conclusions: Face transplantation can address extensive facial and periorbital disfigurement with satisfactory functional and aesthetic outcomes. The majority of FT performed to date have included periorbital components, and postoperative ocular and periocular complications are common. It is critical for ophthalmologists to play a central role in the care of these patients.
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Major Reviews Source Type: research
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in progenito...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: We propose that epigenetics mechanisms involving microRNAs may integrate human transplantation tolerance mechanisms, and regulate key members of the cell death/survival signaling. miR-885-5p could favor cell survival in OT by diminishing the levels of CRADD/RAIDD and CASP3. Nonetheless, given the nature of any complex phenomenon in humans, only cumulative data will help to determine whether this microRNA differential profile may be related to the cause or consequence of operational tolerance. Introduction Despite its clinical success, allotransplantation still faces important challenges, such as preventi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Eva Miko1,2*, Matyas Meggyes1,2, Katalin Doba1, Aliz Barakonyi1,2 and Laszlo Szereday1,2 1Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary 2Janos Szentagothai Research Centre, Pécs, Hungary Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity, transplantation, and tumor immune evasion. Maternal-fetal immunotolerance represents a real immunological chal...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 16 April 2019Source: BurnsAuthor(s): Monica Iliescu Nelea, Laurence Paek, Lan Dao, Nathalie Rouchet, Johnny I. Efanov, Coeugniet Édouard, Michel A. DaninoAbstractBiofilm forms when bacteria surrounded by an extracellular matrix aggregate on a surface. It can develop on many surfaces, including wound dressings; this can be particularly nefarious for burn patients undergoing skin grafting (autograft) for burn wound coverage as they often suffer from compromised immune system function. Autograft donor sites are particularly vulnerable to biofilm formation; as such, timely healing of t...
Source: Burns - Category: Dermatology Source Type: research
More News: Bone Graft | Burns | International Medicine & Public Health