Effects of transcranial direct current stimulation on joint flexibility and pain in sedentary male individuals

Publication date: Available online 19 June 2019Source: Science &SportsAuthor(s): V. Lins, E. Lattari, D. Monteiro, L. Cid, G. Albuquerque Maranhão Neto, S. MachadoSummaryThe aim of this study was to analyze the effects of cathodal tDCS (c-tDCS) on joint flexibility and pain perception in a sedentary male. Eight male healthy, sedentary right-leg-dominant and novice in muscle stretching aged between 19 and 30 years (24.0 ± 4.0 years) were recruited. Subjects performed three experimental conditions in a randomized, double-blinded crossover design: anodal stimulation (a-tDCS), c-tDCS and sham-tDCS (2 mA for 20 minutes targeting the bilaterally motor cortex). Before and immediately after the experimental conditions (baseline and post-condition, respectively), subjects completed the range of motion (ROM) of right hip test and the Visual Analogic Scale for Pain (VAS pain; level of significance P 
Source: Science and Sports - Category: Sports Medicine Source Type: research

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We conducted a questionnaire survey among baseball players at junior high schools across Japan, to understand the practice conditions of players, examining the risk factors of shoulder and elbow pain in baseball players.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
Rotator cuff tears (RCTs) are often associated with severe shoulder pain. However, the mechanism of pain in RCTs is still unknown. In recent years, it has been reported that various neuropeptides, including calcitonin gene-related peptides (CGRP), are involved in knee and hip pain. To reveal the novel mechanism for pain caused by RCTs, we investigated the expression of neuropeptides in a rat RCT model.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
Mesenchymal stem cells (MSCs) possess anti-inflammatory properties and tissue differentiation potential. We prepared a rat shoulder arthritis model by injecting monoiodoacetate (MIA) into the shoulder and investigated the intraarticular administration of MSCs from the aspects of the cartilage protective effect associated with the cell ’s anti-inflammatory activity and inhibition of the central sensitization of pain. When MIA was administered in this model, anti-calcitonin gene related peptide (CGRP) was expressed in the shoulder joint and C5 spinal dorsal horn.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
This article provides a review of the preclinical and clinical pharmacology of lorcaserin, including its pharmacokinetic and safety profiles. Preclinical studies with lorcaserin initially focused on simple measures of food intake and body weight gain, but have now expanded to include studies on its effects on appetitive aspects of feeding behaviour and models of binge-eating. A significant number of studies have also shown that lorcaserin alters behaviours related to drug use and addiction, in rodents and non-human primates. Potential clinically-relevant effects of lorcaserin have also been reported in models of pain and s...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionThe anti-inflammatory effects of X. aethiopica leaves are demonstrated experimentally, thus substantiating its use in folk Medicine. Relevantly, the observed anti-inflammatory properties can stimulate further studies in order to fully unveil the therapeutic potential of the plant, namely as sources of phenolic compounds with a significant ability to interfere with conventional inflammatory targets.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as “ sai ão ” or “ coirama ” . Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, ph...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): M.S. Raghuraman, A. Arthi, M.S. Iswaryarajan Hercule
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
ConclusionThis study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail.ResumoJustificativa e objetivosA calcitonina é um hormônio polipeptídico que regula o metabolismo do cálcio no organismo. Por muitos anos a calcitonina tem sido usada para manter e melhorar a densidade mineral óssea e reduzir a incidência de fraturas. Muitos ...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Abstract Virus vectors have been employed as gene transfer vehicles for various preclinical and clinical gene therapy applications and with the approval of Glybera (Alipogene tiparvovec) as the first gene therapy product as a standard medical treatment (Yla-Herttuala, Mol Ther 20:1831-1832, 2013), gene therapy has reached the status of being a part of standard patient care. Replication-competent herpes simplex virus (HSV) vectors that replicate specifically in actively dividing tumor cells have been used in Phase I-III human trials in patients with glioblastoma multiforme (GBM), a fatal form of brain cancer, and i...
Source: Herpes - Category: Infectious Diseases Authors: Tags: Methods Mol Biol Source Type: research
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