Lack of Decision-making in Patients With Alzheimer's Disease : Functions Involved and the Daily Consequences

Condition:   Alzheimer Disease Interventions:   Diagnostic Test: cognitive assessment;   Other: Inhibition evaluation;   Other: Assessment of mental flexibility;   Other: Evaluation of the update;   Other: working memory;   Other: episodic memory Sponsor:   Centre Hospitalier Universitaire de Saint Etienne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 16 July 2019Source: NeuroImage: ClinicalAuthor(s): Alexa Haeger, Ana S. Costa, Jörg B. Schulz, Kathrin ReetzAbstractCurrent treatment in late-life cognitive impairment and dementia is still limited, and there is no cure for brain tissue degeneration or reversal of cognitive decline. Physical activity represents a promising non-pharmacological interventional approach in many diseases causing cognitive impairment, but its effect on brain integrity is still largely unknown. Especially research of cerebral alterations in disease state that goes beyond observations of clinical improvement...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Rates of Alzheimer's disease are higher in women than in men, and researchers now think they know why.
Source: WebMD Health - Category: Consumer Health News Source Type: news
I recently attended the second Ending Age-Related Diseases conference in New York, hosted by the Life Extension Advocacy Foundation (LEAF). The mix of attendees was much the same as last year: an even split between scientists, entrepreneurs, investors, patient advocates, and interested onlookers, all focused on the treatment of aging as a medical condition. The presentations were similarly a mix of scientists talking about their research programs, entrepreneurs presenting on the data produced by their companies, and investors discussing the state of the industry. For my part, I have already presented several times t...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Nuclear medicine and molecular imaging advocates went to Capitol Hill in Washington,...Read more on AuntMinnie.comRelated Reading: Video from SNMMI 2019: Dr. Barry Siegel on PET reimbursement IMV: PET/CT drives PET scan volume to new heights IDEAS study confirms amyloid PET's value for Alzheimer's Both sides weigh in on plan to loosen radiopharma rules How Medicare fee schedule changes will affect radiology
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 16 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Mousa Zidan, Jasmina Boban, Mladen Bjelan, Aleksandar Todorović, Tijana Stankov Vujanić, Marija Semnic, Nikola Boban, Duško KozićAbstractThe aim of this study was to compare brain volume reduction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) with age-related changes in age- and gender-matched healthy individuals.Sixty-six patients were divided in three groups based on medical history, neurological and neurocognitive assessment: 26 patients with AD, 20 patients with aMCI and ...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
WEDNESDAY, July 17, 2019 -- Rates of Alzheimer's disease are higher in women than in men, and researchers now think they know why. A team from Vanderbilt University Medical Center, in Nashville, Tenn., has identified gender differences in how the...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Taking up three new tasks at the same time boosts mental power and protects against Alzheimer's disease, scientists from California University have found.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, the effect of SAK on spatial discrimination in a rat model of cognitive dysfunction exposed to D-galactose was investigated with respect to its effect on malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels, and on the expressions of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nuclear factor-κB inhibitory factor-α (IκBα) in hippocampus of rats. The results obtained suggest that SAK may exert protective effects on brain cells through anti-oxidation mechanism. Moreover, the improvement in learning and memory impairment by SA...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Authors: Du C, Shi L, Wang M, Mao P, Wang J, Wei Y, Hou J, Wang M Abstract To investigate the effects of emodin on learning and memory and protein kinase C (PKC) signaling pathway in Alzheimer's disease (AD) model mice. 60 APP/PS1 double transgenic AD mice were selected as model mice at the age of 7-8 months, 36 healthy male C57BL/6 mice served as the control group. Morris water maze method and passive avoidance experiment were used to evaluate the memory ability of mice. The thiazole blue (MTT) method and the lactate dehydrogenase (LDH) cytotoxicity test kit were used to evaluate the effect of emodin on the cell v...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
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