Non-linear registration improves statistical power to detect hippocampal atrophy in aging and dementia

Discussion and conclusionNon-linear registration methods were most consistent in determining hippocampal atrophy and because of their better reproducibility, methods, such as ANTs, Elastix and NiftyReg, are preferred for determining hippocampal atrophy rates on longitudinal MRI. Since performances of non-linear registration methods are well comparable, the preferred method would mostly depend on computational efficiency.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research