Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system

ConclusionsIncreased endogenous μ-opioid receptor-mediated neurotransmission is seen in the limbic system of CM patients, especially in right amygdala, which is highly modulated by the attack frequency, pain severity, and sensitivity. This study demonstrates for the first time the negative impact of chronification and exacerbation of headache attacks on the endogenous μ-opioid mechanisms of migraine patients. ClinicalTrials.gov identifier: NCT03004313
Source: NeuroImage: Clinical - Category: Radiology Source Type: research