Pharmacological, biochemical, and histopathological evaluations of cutaneous wound healing property of Mentha piperita aqueous extract ointment

AbstractIn our study, we evaluated cutaneous wound healing potential ofMentha piperita aqueous extract ointment in rats. In vivo design, after creating the cutaneous wound on the back of the rats, the animals were randomly divided into four groups: untreated control, treatment with Eucerin ointment, treatment with 3% tetracycline ointment, and treatment with 3%M. piperita aqueous extract ointment. The groups were treated for 30  days. For biochemical and histopathological analysis of the cutaneous wound healing trend, a 3 × 3 cm section was prepared from all dermal thicknesses on days 10, 20, and 30. The data were analyzed by SPSS-21 software. The use ofM. piperita aqueous extract ointment in the treatment groups led to remarkable reduction (p <  0.05) in the levels of wound area, total cells, neutrophil, lymphocyte, and macrophage and remarkable increase (p <  0.05) in the levels of wound contracture, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and the rate of fibrocyte to fibroblast compared with the control and basal ointment groups. According to the findings,M. piperita aqueous extract ointment can cure the cutaneous wound.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research