Treatment of postscabies prurigo with diflucortolone and chlorquinaldol in a group of African refugees.

We present the results of a study on the effectiveness of a topical combination of diflucortolone and chlorquinaldol. Eighteen African patients who had been previously affected by scabies and treated with permethrin were enrolled. The diagnosis of PSP was made by excluding other causes through microscopic examinations. All patients were treated with the drug combination by two applications daily for two weeks. The primary study objective was to evaluate the itch by a visual analogue scale (VAS) of 0-100. Fifteen patients (83.3%) could be evaluated. All reported improvements: from 86/100 at the start to 29/100 (-57/100) at the end of treatment. Chlorquinaldol, known as an antiseptic agent, demonstrated, according to results of this study, an important anti-itch action. PMID: 31208292 [PubMed - as supplied by publisher]
Source: Tropical Doctor - Category: Tropical Medicine Authors: Tags: Trop Doct Source Type: research

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Discussion Atopic dermatitis (AD) has a prevalence of 3-5% in the overall U.S. population but is increasing with an estimated 10-15% lifetime risk in childhood. It is even more common in children of color with a prevalence in African-American/black children of 17% and Hispanic children of 14%. Health care utilization data also appears to support more severe disease in children of color also. Atopic dermatitis or eczema is a common dermatological skin problem which characteristically is a pruritic, papular eruption with erythema. Like most papulosquamous eruptions it often occurs in intertrigenous areas in people with alle...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Scabies is an infection of the skin, which caused by human itch mite Sarcoptes scabiei. It is a common health problem in Ethiopia, especially during disasters, poor sanitation and overcrowded living condition. Ho...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
Answer toParasite Case of the Week 531:Sarcoptes scabei,var. hominis, the human " itch " mite. Seen here are mites, eggs and fecal pellets (scybala).Old one nicely described the biology and morphology of these arthropods:Sarcoptes scabeioccur in a number of host species. Primarily in swine here in Minnesota but occasionally in humans. The male mites range in size from 213-285 μm long by 162-240 μm wide and the female mites range from 300-504 μm long to 230-420 μm wide.Sarcoptesare round to ovoid when viewed from the back; when viewed from the side they are ventrally flattened and dorsally rounded (sim...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Scabies is a common contagious skin disease caused by an infestation of skin by Sarcoptes scabiei var. hominis. Scabies has two subgroups: ordinary scabies and crusted scabies. Both of these subtypes feature severe pruritus, but precise mechanisms are not fully understood. Herein, we have evaluated the expression of IL-31, an itch-related cytokine mainly produced by activated Th2 T cells, and Th2-related proteins in histopathological sections of ordinary scabies lesions. In scabies lesions, we have detected a larger number of IL-31 (+) cells in the dermis and stronger IL-31 staining of epidermal keratinocytes compared with...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
Abstract Patients with suspected bites or skin rashes regularly present to their primary care physician. Common mite infections encountered in the primary care office include scabies, chiggers, grain itch, and allergic responses from dust mites. In fact, scabies is one of the 50 most prevalent diseases worldwide. Bed bugs are also becoming increasingly common, living in dark crevices, such as mattresses, feeding at night, and causing a maculopapular immune mediated allergic skin response in humans. Proper identification of the mite or bed bug is essential to guide treatment and eradication. PMID: 30115331 [PubMed - in process]
Source: Primary Care - Category: Primary Care Authors: Tags: Prim Care Source Type: research
Patients with suspected bites or skin rashes regularly present to their primary care physician. Common mite infections encountered in the primary care office include scabies, chiggers, grain itch, and allergic responses from dust mites. In fact, scabies is one of the 50 most prevalent diseases worldwide. Bed bugs are also becoming increasingly common, living in dark crevices, such as mattresses, feeding at night, and causing a maculopapular immune mediated allergic skin response in humans. Proper identification of the mite or bed bug is essential to guide treatment and eradication.
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Source Type: research
by Dorien T. Beeres, Sofanne J. Ravensbergen, Annelies Heidema, Darren Cornish, Machiel Vonk, Leonie D. Wijnholds, Jessica J. H. Hendriks, Johanneke Kleinnijenhuis, Till F. Omansen, Ymkje Stienstra Scabies is a skin infestation with the miteSarcoptes scabiei causing itch and rash and is a major risk factor for bacterial skin infections and severe complications. Here, we evaluated the treatment outcome of 2866 asylum seekers who received (preventive) scabies treatment before and during a scabies intervention programme (SIP) in the main reception centre in the Netherlands between January 2014 and March 2016. A SIP was intro...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Itch is the cardinal symptom of scabies, present in more than 90% of the cases, generalized and intense, worsening at night, and often sparing the head. The primary complications of the itch in scabies are secondary bacterial infections and psychosocial issues leading to impairment on life quality. Currently, there are no specific data analyzing mechanisms of the itch in scabies, but the latest progress made in the understanding of host-mite interactions may help to improve understanding. Management of itch in scabies consists primarily of the treatment of the mite infestation, but sometimes the itching sensation may persi...
Source: Dermatologic Clinics - Category: Dermatology Authors: Source Type: research
Unbearable itch is the most common symptom of scabies infestations, which affects more than 100 million people worldwide. However, the underlying pruritic mechanism is not well understood. The expression levels of several known itch mediators (histamine, TRPV1, TRPA1, tryptase, PAR2, and B-tubulin for epidermal nerve quantification) were examinded in scabies-infested and control skin of human subjects and a pig model. Skin biopsies from 6 scabies patients, 4 healthy volunteers, and 3 pigs (one infected ear and contralateral control ear) underwent immunohistochemistry.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
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