Pure viral sepsis secondary to Community-Acquired Pneumonia in adults: risk and prognostic factors

We investigated the risk and prognostic factors of pure viral sepsis in adult patients with community-acquired pneumonia (CAP), using the Sepsis-3 definition. Pure viral sepsis was found in 3% of all patients admitted to the emergency department with a diagnosis of CAP (138 out of 4,028), 19% of all CAP patients admitted to the intensive care unit (ICU) (138 out of 722) and 61% of all patients with a diagnosis of viral CAP (138 out of 225). Our data indicate that males and patients aged ≥65 years are at increased risk of viral sepsis
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Conclusions: The clinical features and outcomes of pandemic (H1N1) 2009 influenza and current circulating seasonal influenza A strains were comparable in hospitalised patients. However, since both seasonal and pandemic influenza can lead to significant morbidity and mortality, the impact of pre-existing seasonal influenza should not be underestimated during the pandemic period. PMID: 31304711 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Nawal CL, Agarwal S, Agrawal A, Prakash R, Mital P, Singh A, Chejara RS Abstract Introduction: The resurgence of epidemic of Influenza A (H1N1) pdm 09 was phenomenal in 2015 and has become an annual phenomenon. Antigenic drift and reassortment is the rule rather than exception, conferring survival benefit to the virus. As this disease has high mortality, we compared the clinico-epidemiological profile of patients expired in the year 2015 due to "A/California/7/2009" strain with those of expired in the year 2018 due to "A/Michigan/45/2015" strain. Material and Method: We collected da...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Editor ’s PerspectiveWhat We Already Know about This TopicFor most bacterial pneumonia, the lung interstitium is considered to be the site of infection, and adequate antibiotic concentrations are important for drug effectDespite systemic antibiotic therapy, therapeutic failure is common, perhaps due to poor lung penetration, and resulting low interstitial space fluid antibiotic concentrationsIncreasing systemic antibiotic doses in order to increase interstitial space fluid antibiotic concentrations could lead to toxicities such as nephrotoxicityWhat This Article Tells Us That Is NewIn a mechanically ventilated health...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
Publication date: Available online 15 July 2019Source: Respiratory Medicine Case ReportsAuthor(s): Yanqiu Wei, Peng Chen, Huihui Yue, Gaohong Sheng, Jiaojiao Chu, Hui-Lan ZhangAbstractGiant cell interstitial pneumonia (GIP) is an exceedingly rare lung disease, usually due to occupational exposure to hard-metal compounds (tungsten, carbide, cobalt). Diagnosis of GIP is mainly based on the presence of multinucleated giant cell (MNGC) in alveolar spaces by histologic examination. Here, we present a case of GIP with multi-organ involvement. A 63-year-old man was diagnosed with tuberculosis firstly, but conventional treatment d...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
We describe host inflammatory biomarkers and clinical outcomes among children hospitalized with RSV lower respiratory tract infection (LRTI) in Uganda and controls with rhinovirus and pneumococcal pneumonia. Methods: 58 children hospitalized with LRTI were included. We compared 37 patients with RSV, 10 control patients with rhinovirus and 11 control patients with suspected pneumococcal pneumonia. Results: Patients in the RSV group had significantly lower levels of C-reactive protein (CRP) and chitinase-3-like protein 1 (CHI3L1) than the pneumococcal pneumonia group (P
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Translational Medicine Reports Source Type: research
Conclusions Cystic fibrosis or CFTR-RD can present as ARP/CP. Complete diagnostic testing for CFTR-RD in patients with ARP/CP will broaden treatment options and help to identify comorbid illness.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
Background: Investigations of the relationship between vancomycin trough concentrations and area under the concentration time curve (AUC) are growing, but still limited. The authors sought to determine vancomycin exposure among hospitalized adults with presumed or confirmed invasive staphylococcal infections using 2-level pharmacokinetic monitoring to inform changes to an institutional vancomycin dosing protocol. Methods: This was a retrospective observational study performed in 2 acute care hospitals. Adults prescribed vancomycin (therapeutic trough 15–20 mg/L) for a presumed or documented invasive staphylococc...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
In conclusion, patients with CHH may develop adult-onset immunodeficiency or malignancy without preceding clinical symptoms of immune defect, warranting careful follow-up. Variable disease course and risk factors for mortality should be acknowledged.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionProteomic analysis pointed to impairment of lipid metabolism as a major change in septic patients secondary to HAP, which was further validated by the reduced levels of cholesterol moieties and apolipoproteins in plasma. Our results stress the involvement of lipids in the pathogenesis of sepsis, which is in accordance with previous reports supporting the role of lipid moieties in pathogen toxin clearance and in modulating inflammatory responses.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research
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