Effects of computerized cognitive training as add-on treatment to stimulants in ADHD: a pilot fMRI study

AbstractThe neurofunctional effects of Cognitive training (CT) are poorly understood. Our main objective was to assess fMRI brain activation patterns in children with ADHD who received CT as an add-on treatment to stimulant medication. We included twenty children with ADHD from a clinical trial of stimulant medication and CT (10 in medication + CT and 10 in medication + non-active training). Between-group differences were assessed in performance and in brain activation during 3 fMRI paradigms of working memory (N-back: 0-back, 1-back, 2-back, 3-back), sustained attention (Sustained Attention Task - SAT: 2  s, 5 s and 8 s delays) and inhibitory control (Go/No-Go). We found significant group x time x condition interactions in working memory (WM) and sustained attention on brain activation. In N-back, decreases were observed in the BOLD signal change from baseline to endpoint with increasing WM load in the right insula, right putamen, left thalamus and left pallidum in the CT compared to the non-active group; in SAT - increases in the BOLD signal change from baseline to endpoint with increasing delays were observed in bilateral precuneus, right insula, bilateral associative visual cortex and an gular gyrus, right middle temporal, precentral, postcentral, superior frontal and middle frontal gyri in the CT compared to the non-active group. CT in ADHD was associated with changes in activation in task-relevant parietal and striato-limbic regions of sustained attention...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research

Related Links:

Some 1.35 million people die and more than 50 million are injured or disabled from road accidents annually across the globe. Driving is a complex task with multiple complex cognitive functions, including perception, motor coordination, and executive functi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 17 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Zeynep Selen Karalok, Zeynep Öztürk, Altan GunesAbstractThe aim of this study is to evaluate the abnormal cortical structures associated with newly diagnosed benign epilepsy with centrotemporal spikes (BECTS) patients and assessed the effects of comorbid attention-deficit/hyperactivity (ADHD) on these abnormalities. Newly diagnosed BECTS patients (n = 33, 23 males) and age-matched healthy controls (n = 48) were evaluated by surface and volumetric MRI. CAT12 toolbox (HYPERLINK “http://www.neuro.uni-jena....
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
THURSDAY, July 18, 2019 -- Athletes with attention-deficit/hyperactivity disorder (ADHD) with concussion seem to have longer recovery than controls, regardless of their psychostimulant medication status, according to a study presented at the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
As awful for health as they are, having played such a huge role in childhood breakfasts, thoughts of breakfast cereals still conjure up a host of memories. Deep within the haze of my childhood memories, buried beneath recollections of nerdy high school days, a marriage gone sour, and a brother-in-law midlife crisis involving duct tape, three members of the local PTA, and a VW bus, are images of the mornings I sat with my two sisters at our kitchen table in suburban New Jersey, each of us slurping a bowl of Trix, Lucky Charms, or Fruit Loops cereal, still recovering from a late night of Bewitched and Mission Impossible. We ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Breakfast cereal grain-free wheat belly Source Type: blogs
A 2-year-old male pediatric patient experienced a partial occlusion of the internal carotid and subsequent asphyxiation resulting in hypoxic brain injury that was later misdiagnosed as primary attention deficient hyperactivity disorder (ADHD). Imaging anal...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Authors: Tran K, Wu J Abstract A 2-year-old male pediatric patient experienced a partial occlusion of the internal carotid and subsequent asphyxiation resulting in hypoxic brain injury that was later misdiagnosed as primary attention deficient hyperactivity disorder (ADHD). Imaging analyses using diffusion tensor imaging (DTI), positron emission tomography (PET), and magnetic resonance imaging (MRI) quantitative volumetrics (QV) were used nine years following the incident to identify whether his development of ADHD is of a primary heritability or secondary hypoxic brain injury sequelae. The patient's DTI analysis g...
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
Conclusions: Lithium carbonate is a viable, efficacious and well tolerated alternative to various neuroleptics and other psychotropic medications for use as a mood stabilizer for patients with ASD. PMID: 31308580 [PubMed - in process]
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
The involvement of mitochondrial dysfunction in the pathophysiology of attention-deficit hyperactivity disorder (ADHD) has been suggested in several reports. Mitochondrial DNA (mtDNA) copy number, as well as methylation of the D-loop region and peroxisome-proliferator-activated receptor γ co-activator-1α (PPARGC1A), are considered biomarkers for mitochondrial dysfunction. We compared the mtDNA copy number and methylation ratio of the D-loop region and PPARGC1A between ADHD patients and controls. The present study included 70 subjects with ADHD and 70 age- and gender-matched healthy controls (HCs). The relative ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionsOur results suggest that there may be similarly inefficient cognitive emotional regulation skills leading to ED in both disorders (ADHD and BPD). However, ADHD patients showed a higher use of adaptive cognitive emotional strategies and a lower level of ED than BPD patients.
Source: Borderline Personality Disorder and Emotion Dysregulation - Category: Psychiatry Source Type: research
AbstractAttention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric condition in childhood and adolescence. Psychoeducation has been recommended by different guidelines as an initial treatment for ADHD, however the effects of the intervention for reducing symptoms and improving other outcomes still need to be established. This systematic review investigated the magnitude of impact that psychoeducation interventions have on various outcomes in children with ADHD. A systematic review of articles published between 1990 and 2018 was conducted of treatment outcome studies that investigated the effects of...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
More News: ADHD | Brain | Children | Clinical Trials | Computers | Neurology | Study | Training | Universities & Medical Training