The art of diminutive polypectomy and the tools we use: Is there a best practice?
A key to successful colorectal cancer (CRC) prevention is complete colon polyp removal. The quality of colonoscopy is currently defined by how well we identify neoplastic lesions, as measured by adenoma detection rates (ADRs). A higher ADR correlates with lower rates of interval colon cancers.1 However, the completeness and skills of resection are important factors as well, but they are not current quality metrics and would be an onerous task to measure in daily practice.
ConclusionAmong patients under age 50, advanced adenomas and ≥ 10-mm serrated polyps were predominantly in the distal colorectum. Advanced adenomas tended to be found in patients aged 45–49. Our results might explain the rising trend of distal colorectal cancer and emphasize the necessity for colonoscopy screening among these populations.
ConclusionPatients with attenuated familial adenomatous polyposis (
Spoiler: Medically graphic image of colon A 17-year-old male is referred for colorectal cancer screening following his father’s diagnosis of metastatic colorectal cancer at the age of 47. He is asymptomatic and otherwise well. Colonoscopy reveals hundreds of adenomatous polyps throughout the colon, and he eventually undergoes a total proctocolectomy with ileal pouch anal anastomosis. Which of the following extracolonic... What malignancy is this patient at risk for?
AbstractPurpose of reviewTo present the current understanding of the diagnosis, management, and potential genetic causes of serrated polyposis syndrome.Recent findingsThe clinical criteria for serrated polyposis syndrome was recently updated and now includes individuals with five or more serrated polyps proximal to the rectum that are 5 mm in size or greater and at least two that are 10 mm in size of greater as well as individuals with 20 or more serrated polyps throughout the colon with at least five proximal to the rectum. There is a significant risk for colon cancer in first-degree relatives of individuals with serrated...
CONCLUSION: Our study provides the first identification of a panel of three plasma circRNAs that could serve as a novel and independent diagnostic biomarker for CRC. PMID: 31669510 [PubMed - as supplied by publisher]
Contributors : Li Jingyun ; Rui WangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensPatients with germline APC mutations are recognized by hundreds of adenoma polyps in colon, which will give rise to adenocarcinoma inevitably. Over 700 germline APC mutations have been reported to be the leading cause of adenomatous polyposis. However, the underlying mechanism of APC mutation triggered colonic cancer remains mysterious. Here, using a modified STRT-seq protocol, we analyzed over 4000 single cells from the four matching adenomatous polyposis, adenocarcinoma, adjacent normal colon...
In this study, ApcMin/+ intestinal adenoma mice were generated on TLR4-sufficient and TLR4-deficient backgrounds to investigate the carcinogenic effect of TLR4 in mouse gut by comparing mice survival, peripheral blood cells, bone marrow haematopoietic precursor cells and numbers of polyps in the guts of ApcMin/+ WT and ApcMin/+ TLR4-/- mice. The results revealed that TLR4 had a critical role in promoting spontaneous intestinal tumorigenesis. Significant differential genes were screened out by the high-throughput RNA-Seq method. After combining these results with KEGG enrichment data, it was determined that TLR4 might promo...
ConclusionThe fluorescent marking clips were easily placed and recognized with a fluorescent laparoscope. This method is expected to be safe and risks of accidental puncture related to tattoo marking method can be reduced or almost eliminated.
ConclusionThe fusion fascia of Fredet is useful to achieve CME and D3-L in right colon cancers with reduced risk of intraoperative complications. This structure is particularly suitable for minimally invasive surgery; therefore, we encourage awareness of the fascia of Fredet by colorectal surgeons.
Conclusions: We suggested that GB polyps are associated with proximal colon polyps. Colonoscopy may be a more effective strategy for screening proximal precancerous lesions among patients with GB polyps. The association between GB disease and colon polyps demands further prospective investigation. PMID: 31611916 [PubMed]