Helicobacter suis infection is associated with nodular gastritis ‐like appearance of gastric mucosa‐associated lymphoid tissue lymphoma

In this study, we compared clinicopathological characteristics and prevalence of non ‐Helicobacter pylori Helicobacter (NHPH) infection between common type mucosa ‐associated lymphoid tissue (MALT) lymphoma and MALT lymphoma with nodular gastritis‐like appearance (M‐NGA).H suis infection was detected in 4/4 cases of M ‐NGA. Our study indicates that NHPH infection may be one of the causes of the pathogenesis of M‐NGA and that eradication therapy should be the first‐choice treatment for M‐NGA associated with NHPH infection. AbstractMost patients with gastric mucosa ‐associated lymphoid tissue (MALT) lymphoma are infected withHelicobacter pylori, and eradication therapy is the first ‐line treatment for localized disease withH pylori infection. However, there were several reports showing effectiveness of eradication therapy in evenH pylori negative cases. Gastric MALT lymphomas are endoscopically classified into three common types: superficial, ulcerative, and elevated types. For the past 20  years, we have encountered 200 cases of localized gastric MALT lymphoma. Among them, only 4 cases (2%) showed similar macroscopic findings to those of nodular gastritis (gastric MALT lymphoma with nodular gastritis‐like appearance; M‐NGA). Here, we compared clinicopathological characteristics and prevalence of non‐H pylori Helicobacter (NHPH) infection between M ‐NGA and other common types of gastric MALT lymphoma. To examine the prevalence of NHPH infection, DNA...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research