Role of 18F-FLT PET/CT in suspected recurrent or residual lymphoma: final results of a pilot prospective trial

ConclusionsAccording to our results in a clinical setting of recurrent or residual lymphoma, FLT is not significantly superior to FDG and it is unlikely that it will be employed independently. FLT may be restricted to a few specific cases, as complementary to standard FDG imaging, to confirm a diagnosis or to define a better target to biopsy. However, due to FLT suboptimal performance, many findings would remain inconclusive, requiring further diagnostic procedures and reducing the effectiveness of performing an additional FLT scan.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research

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We report the case of a 62-year-old woman with previous history of stage III Hodgkin lymphoma. Routine follow-up CT scan revealed 2 years after end of treatment the appearance of mediastinal nodes, suspected of lymphoma recurrence. An 18F-FDG PET/CT was performed showing hypermetabolic mediastinal lymph nodes with diffuse symmetric osteomedullar hypermetabolism of pelvis and scapulae. In the hypothesis of either recurrence or multisystemic inflammatory disorder, bone marrow and lymph node biopsies were performed, revealing the presence of noncaseating epithelioid cell granulomas, leading to the diagnosis of multisystemic s...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Conclusions: Focal increased FDG metabolic activity in the parotid gland require further investigation especially in the head and neck malignancy or if the results may change treatment plan as many will have unexpected metastasis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Posters Source Type: research
​Seventy-five percent of trauma injuries involve some kind of thoracic insult, a quarter of which need a procedural intervention like a chest tube. (Surg Clin North Am 2007;87[1]:95; Long-term illness, lung disease, and post-operative complications may cause pleural effusions or a pneumothorax, so treating these conditions quickly can significantly decrease patient morbidity and mortality. Other indications for chest tube placement include:Trauma: Pneumothorax, hemopneumothorax, or tension pneumothoraxLong-term illness: Pleural effusion (cancer, pneumonia)Infection: Empyema, purulent pleuriti...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
We present here preliminary descriptive data on the patients' characteristics and their established diagnosis at follow-up.Methods: Since 2015, all patients aged ≥15 years and referred to the hematology or internal medicine department in 117 French hospitals, with an unexplained SM diagnosis (confirmed by echography or CT-scan with a craniocaudal length ≥13 cm) have been invited to participate. Unexplained cause of SM was defined as a first negative clinical workup based on patient's interview and physical examination, and biological routine tests (including complete blood and reticulocytes count, clotting test, live...
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster III Source Type: research
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and positron emission tomography (PET) standard uptake values (SUV) are useful methods for evaluating mediastinal lymph node pathology.The aim this study was to compare EBUS TBNA and PET suv results in benign, granulomatous and malignant disease. The files of 151 patients who had FDG-PET scanning and underwent EBUS-TBNA between 2015-2017 were reviewed. The diagnoses were confirmed by needle aspiration cytology, histopathology and clinical follow-up. Malignant diseases included lung cancers, metastasis and lymphomas. Granulomatous diseases were mai...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusion18F-FDG PET/CT can be a useful tool for scanning the whole body to suggest the FUO cause.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
We report a case of a 52-year-old female with irritable cough. CT showed a lung mass with multiple bilateral lung nodules, and sarcoidosis was suspected. F-18 FDG PET/CT was undertaken for the diagnosis and showed intense uptake of FDG in the mass in the lower lobe of the right lung, multiple lymph nodes, liver, and spleen. The maximum standardized uptake value of F-18 FDG was 43.58. This pattern of involvement most likely represents lymphomatous involvement. Diagnoses: Histopathology suggested tubercular involvement. Intervention and outcomes: The patient received anti-TB treatment and recovered. Lessons: Abovementione...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion: In this educational exhibit’s review of various imaging findings of IgG4-related diseases, FDG-PET/CT was highlighted as an effective tool for assessing the location of lesions, particularly those that are difficult to detect with conventional imaging methods (e.g., central nerve and cardiovascular lesions without symptoms). Nuclear medicine professionals, who have a chance to diagnosis systemic diseases, will be able to understand potential of metabolism imaging and appropriately evaluate those studies. Research Support: None
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Posters Source Type: research
Conclusion: For evaluation of indeterminate lymphadenopathy in this population, FDG PET/CT had very poor PPV (i.e., frequent false positive results with benign / inflammatory etiologies, as would be expected) but had very high NPV of 97%. Such strong NPV renders malignancy very unlikely in cases where FDG PET is negative (representing 33% of patients in this cohort), which may allow for more confident observation of FDG-negative cases thus potentially avoiding costly and invasive procedures such as EBUS, mediastinoscopy or CT-guided biopsies, especially in elderly patients. Research Support: N/A
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lymphoma - Adult Source Type: research
A 54-year-old woman presented to our outpatient ophthalmology clinic complaining of eye redness, severe pain and photophobia that had persisted for 1  day. Slit lamp examination revealed she was found to have large greasy-white mutton-fat keratic precipitates on the endothelial surface of her both eyes. Physical examination showed bilateral cervical lymphadenopathy and multiple tender erythematous nodular skin swellings on both shins. The patie nt’s previous medical history did not suggest trauma, insect bite, diabetes mellitus or tuberculosis. The patient had previously received the Bacille Calmette Gué...
Source: QJM - Category: Internal Medicine Source Type: research
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