Optimization of the process variables of roller compaction, on the basis of granules characteristics (flow, mechanical strength and disintegration behavior): An application of SeDeM-ODT expert system.

Optimization of the process variables of roller compaction, on the basis of granules characteristics (flow, mechanical strength and disintegration behavior): An application of SeDeM-ODT expert system. Drug Dev Ind Pharm. 2019 Jun 18;:1-37 Authors: Khan A Abstract Objective of the study was application of SeDeM-ODT expert system for optimization of process variables for roller compaction and for the preparation of granules with better flow, compressibility and disintegration behavior. In the present study, granules were prepared at pre-determined (on the basis of factorial design) process variables and characterized using SeDeM-ODT expert system. Compatibility of ribavirin with excipients (microcrystalline cellulose, tablettose-80, cross carmellose sodium and magnesium stearate) was evaluated by binary mixture approach, using FTIR. According to SeDeM-ODT expert system, granules were characterized for various parameters related to flow, compressibility and disintegration behavior and Index of Good Compressibility and Bucodispersibility (IGCB index) was calculated. The process variables resulting in highest IGCB value were considered as optimum. Ribavirin was found compatible with all the excipients used in the study and characteristics peaks were present in FTIR spectra after subjecting to stress conditions (75% relative humidity at 45 ± 5 °C) for 30 days. Both Ribavirin powder and Ribavirin containing powder blend had poor flo...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research