Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients.

Conclusion: Vascular abnormalities of the liver were commonly observed in thioguanine treated IBD patients, although these were not progressive and remained of limited clinical relevance over time. PMID: 31203688 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

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Authors: Baltazar D, Haag C, Gupta AS, Marzano AM, Ortega Loayza AG Abstract Pyoderma gangrenosum (PG) is a rare, ulcerative inflammatory skin disease that most commonly occurs in patients with inflammatory bowel disease, rheumatologic diseases, or hematologic diseases. Successful treatment of PG often requires immunosuppression and appropriate wound care. Systemic corticosteroids and cyclosporine are the first-line treatments for PG. However, chronic use of these systemic agents places patients at risk for developing significant side effects, including hyperglycemia, osteoporosis, hypertension, and weight gain. Fu...
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
A 60-Year-Old Woman With Acute Chest Pain and Bilateral Pleural and Pericardial Effusions. Chest. 2019 Jun;155(6):e167-e170 Authors: Orr L, DeSilva P, Datta D Abstract CASE PRESENTATION: A 60-year-old woman presented with acute-onset, progressively worsening shortness of breath and pleuritic chest pain for 3 days. She also complained of a dry cough, but no fever or chills. There was no history of swelling of the feet; nor was there a history of nausea or diarrhea. She was a lifelong nonsmoker and had no history of recent travel or sick contacts. Her medical history included hypertension and ...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Purpose of review Enteric hyperoxaluria is commonly observed in malabsorptive conditions including Roux en Y gastric bypass (RYGB) and inflammatory bowel diseases (IBD). Its incidence is increasing secondary to an increased prevalence of both disorders. In this review, we summarize the evidence linking the gut microbiota to the risk of enteric hyperoxaluria. Recent findings In enteric hyperoxaluria, fat malabsorption leads to increased binding of calcium to free fatty acids resulting in more soluble oxalate in the intestinal lumen. Bile acids and free fatty acids in the lumen also cause increased gut permeability allo...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: RENAL PATHOPHYSIOLOGY: Edited by Orson W. Moe and Susan E. Quaggin Source Type: research
We pay special attention to restoration of magnesium in the Wheat Belly lifestyle. This is because magnesium deficiency is universal, affecting virtually everyone, is severe, and has substantial implications for health. But why? Why has everyone become so depleted in magnesium in the modern world? There are five major reasons: Water filtration—We filter our water out of necessity, since modern waterways are contaminated by sewage runoff, pesticide/herbicides, algal overgrowth, etc. So, rather than drinking from a nearby stream or river that runs freely over rocks and minerals rich in magnesium, we drink water filter...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Magnesium grain-free phytates undoctored wheat belly Source Type: blogs
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsIN-associated AEs were identified among patients with UC, with liver dysfunction often being reversible, while surgical resection was required in a high proportion of patients who developed intussusception. Both healthcare workers and patients should adequately recognize the potential for AEs with the use of IN.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
“Once you learn the art of relaxation, everything happens spontaneously and effortlessly.” – Amma During hectic times, it’s tough to remember that relaxation is more than a luxury. In fact, humans need to relax to maintain balance in their lives. Work stress, family strife, and mounting responsibilities can exact a tremendous toll. Relaxing should be at the top of the list as a healthy coping measure and as a rewarding self-gift. Why do we so often neglect this healing self-care? Do you know the healthiest ways to relax your mind, body and soul? Perhaps the biggest obstacle to relaxing is that some ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Mental Health and Wellness Mindfulness Self-Help Source Type: blogs
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many stag...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion: Periodontal disease is significantly and positively correlated with increased risk of hypertension in Chinese population, and exact mechanisms of this association should be explored in future. Introduction Periodontal disease is a complex polymicrobial inflammation, including gingivitis and periodontitis. According to the 2015 Global Burden of Disease (GBD) study, the prevalence of severe chronic periodontitis in 2015 has reached 616 million (Kassebaum et al., 2017). In China, the periodontal disease standardized DALYs rate has risen from 24.7 in 1990 to 25.7 in 2013 according to the data from 2013 GBD ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Millennials are often credited with driving the $4.2 trillion global wellness market, with their love of pursuits like yoga, meditation and boutique fitness. But despite their reputation for valuing health and wellness, millennials are in worse health than their elders in Generation X used to be, according to a new report from the Blue Cross Blue Shield Association. Millennials — who in 2017 were ages 21 to 36 — were overall in good health that year, according to Blue Cross’s data analysis of 55 million commercially insured millennials. But around age 27, millennials’ health began to decline —...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
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