Design, synthesis and biological evaluation of anti-tuberculosis agents based on Bedaquiline structure.

CONCLUSION: The results of in vitro anti-tuberculosis activity assays, docking studies and ADMET predictions indicate that the synthesized compounds have potential antifungal activity, with compounds 6a1 being further optimized and developed as lead compounds. PMID: 31203803 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31203803?dopt=Abstract

Source: Medicinal Chemistry - June 11, 2019 Category: Chemistry Authors: Wu C, Luo J, Wu M, Meng F, Cai Z, Chen Y, Sun T Tags: Med Chem Source Type: research