Highly potent and selective ectonucleoside triphosphate diphosphohydrolases (ENTPDase1, 2, 3 and 8) inhibitors having 2-substituted-7-trifluoromethyl-thiadiazolopyrimidones scaffold.

CONCLUSIONS: The docking analysis proposed that the inhibitory activity correlates with the hydrogen bonds inside the binding pocket. Thus, these derivatives are of interest and may further be investigated for their importance in medicinal chemistry. PMID: 31203806 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research