Oral Habits—Part 1: The Dental Effects and Management of Nutritive and Non-nutritive Sucking

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Literature Reviews Source Type: research

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Publication date: May 2019Source: The Journal of Molecular Diagnostics, Volume 21, Issue 3Author(s): Jennifer Tyler, Lorie Kumer, Carolyn Fisher, Heather Casey, Hiroko ShikeChimerism testing is used to monitor engraftment and risk of relapse after allogeneic hematopoietic stem cell transplantation for hematologic malignancies. Although short tandem repeat (STR) method is widely used among clinical laboratories, quantitative PCR (qPCR) provides better sensitivity (0.1%) than STR (1% to 5%) but is less accurate than STR for patients in mixed chimerism. qPCR chimerism allows evaluation of residual recipient cells as a surroga...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: May 2019Source: The Journal of Molecular Diagnostics, Volume 21, Issue 3Author(s):
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: May 2019Source: The Journal of Molecular Diagnostics, Volume 21, Issue 3Author(s):
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
This study was performed to establish a reference system for performance evaluation of BRCA genetic testing and variant interpretation, which includes interpretation rules, reference materials (RMs), and a reference database (RD). BRCA1/2 mutations identified in cell lines and clinical cases were selected to establish RMs. All mutations were detected by NGS and validated by Sanger sequencing. Variant call format files and standard variant data sets were collected and annotated to build the RD. Participant laboratories were invited to validate this reference system. Interpretation rules for BRCA variants in the Chinese popu...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
In this study, a novel sequencing strategy based on a unique double-barcode design was established. The results showed that when single barcode-based analysis strategy was used, cross-contamination level of 20 DNA samples ranged from 0.27% to 11.90% on Hiseq 2500 and from 0.93% to 17.70% on Hiseq X ten, whereas double barcode–based strategy could effectively eliminate cross-contamination. Moreover, the data indicated that cross-contamination was mainly derived from capture process and significantly affected by different NGS platforms. In addition, contamination level was negatively related to sequencing depth. Moreov...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
We describe herein the development and clinical validation of a 28 gene cell-free DNA panel that targets the most common genetic alterations in solid tumors. Bioinformatic and variant filtering solutions were developed to improve test sensitivity and specificity. The panel and these tools were used to analyze commercially available controls, allowing establishment of a limit of detection allele frequency cutoff of 0.25%, with 100% (95% CI: 81.5% to 100%) specificity and 89.8% (95% CI: 81.0% to 94.9%) sensitivity. In addition, we analyzed a total of 163 blood samples from patients with metastatic cancer (N=123) and demonstr...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: Available online 23 April 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Dana S. Clutter, Gelareh Mazarei, Ruma Sinha, Justen Manasa, Janin Nouhin, Ellen LaPrade, Sara Bolouki, Philip L. Tzou, Jessica Hannita-Hui, Malaya K. Sahoo, Peter Kuimelis, Robert G. Kuimelis, Benjamin A. Pinsky, Gary K. Schoolnik, Arjang Hassibi, Robert W. ShaferA point-of-care HIV-1 genotypic resistance assay that could be performed during a clinic visit would enable care providers to make informed treatment decisions for patients starting therapy or experiencing virological failure on therapy. The main challenge for s...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
CONCLUSIONS: The new German short version, the SBI-6R-D, is an economic, reliable and valid questionnaire to measure spiritual and religious attitudes. PMID: 31013524 [PubMed - as supplied by publisher]
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
We present the case of a 56-year-old female presenting with bilateral foot pain. Imaging reveals symmetrical abductor digiti minimi atrophy associated with bilateral plantar fasciitis. These appearances are well demonstrated on both magnetic resonance imaging and ultrasound.
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 23 April 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Bertrand Boyer, Barbara Bordini, Dalila Caputo, Thomas Neri, Susanna Stea, Aldo ToniAbstractBackgroundBilateral cases, representing at least 25% of total knee arthroplasties (TKA), could convey a statistical bias linked to dependency. Registries allow exploring this issue, susceptible to question surgeon validated protocols. Do bilateral total knee arthroplasties behave differently than unilateral knees in terms of implant survival?HypothesisBilateral TKA have a better survival than unilateral TKA.Patient...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
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