The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach

We report on 674 individuals who met standard eligibility criteria (282 AD-affected participants [42% of the sample], 115 individuals with mild cognitive impairment (MCI) [17% of the sample], and 277 cognitively healthy individuals [41% of the sample]). There are 43 possible multiplex families (10 families with 4 or more AD-affected members and 3 families with 3 AD-affected members). Most individuals in our cohort were ascertained from the Metro, Bayaman, and Cauguas health regions. Across health regions, we found differences in ancestral backgrounds and select clinical traits.
Discussion: The multisource ascertainment approach used in the PRADI study highlights the importance of enlisting a broad range of community resources and providers. Preliminary results provide important information about our cohort that will be useful as we move forward with ascertainment. We expect that results from the PRADI study will lead to a better understanding of genetic risk for AD among this population.

Source: Frontiers in Genetics - June 18, 2019 Category: Genetics & Stem Cells Source Type: research