miRNome Reveals New Insights Into the Molecular Biology of Field Cancerization in Gastric Cancer

Conclusion: Our results show that gastric cancer and adjacent tissues have an expression profile for miRNAs analyzed very similar, indicating that miRNAs studied are intimately associated with field cancerization in gastric cancer. The overexpression of TS-miRs in adjacent tissue is likely an antitumor mechanism. Additionally, these miRNAs have great accuracy in discriminating non-cancer from other tissues and can be potentially useful as biomarkers for gastric cancer.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research