Intravenous antibiotic use and exacerbation events in an adult cystic fibrosis centre: A prospective observational study

In CF, people with higher FEV1 are less aggressively treated with intravenous (IV) antibiotics, with resultant negative impact on their health outcomes. This could be entirely clinician-driven, but patient choice may also influence IV use. In this prospective observational study, we explored IV recommendations by clinicians and IV acceptance by adults with CF to understand how clinical presentations consistent with exacerbations resulted in IV use.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research

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Conclusions Cystic fibrosis or CFTR-RD can present as ARP/CP. Complete diagnostic testing for CFTR-RD in patients with ARP/CP will broaden treatment options and help to identify comorbid illness.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
Condition:   Cystic Fibrosis Intervention:   Device: Fitbit Tracker Sponsors:   Medical College of Wisconsin;   Cystic Fibrosis Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Intervention:   Behavioral: Motivational Interviewing Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Intervention:   Device: Fitbit Tracker Sponsors:   Medical College of Wisconsin;   Cystic Fibrosis Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsSPX-101 was well-tolerated across a range of doses and had little/no systemic exposure in healthy adults and adults with CF, thus supporting further study in patients with CF.Clinicaltrial.gov registrationNCT03056989.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Condition:   Cystic Fibrosis Intervention:   Behavioral: Motivational Interviewing Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Intervention:   Device: Fitbit Tracker Sponsors:   Medical College of Wisconsin;   Cystic Fibrosis Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Gene Therapy, Published online: 12 July 2019; doi:10.1038/s41434-019-0092-5Beyond cystic fibrosis transmembrane conductance regulator therapy: a perspective on gene therapy and small molecule treatment for cystic fibrosis
Source: Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
Condition:   Cystic Fibrosis Intervention:   Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Cystic Fibrosis;   Death;   Lung Transplantation Intervention:   Diagnostic Test: Lung function testing Sponsors:   University Hospital Inselspital, Berne;   Lindenhofspital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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