Near Adult Height in Girls with Turner Syndrome Treated with Growth Hormone Following Either Induced or Spontaneous Puberty

To understand whether spontaneous vs induced puberty and the type and route of estrogen influence the height of girls with Turner syndrome on growth hormone (GH).
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Article Source Type: research

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Publication date: Available online 12 July 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Dr Asmahane Ladjouze, Dr Malcolm DonaldsonAbstractThe term primary gonadal failure encompasses not only testicular insufficiency in 46,XY males and ovarian insufficiency in 46,XX females, but also those disorders of sex development (DSD) which result in gender assignment that is at variance with the genotype and gonadal type. In boys, causes of gonadal failure include Klinefelter and other aneuploidy syndromes, bilateral cryptorchidism, testicular torsion, and forms of 46,XY DSD such as partia...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Abstract The aim of this study was to discuss the association between serum adipokines levels and metabolic indicators in girls with Turner syndrome. PMID: 31310897 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Publication date: Available online 12 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): David M. Overman
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Wit JM, Deeb A, Bin-Abbas B, Al Mutair A, Koledova E, Savage MO Abstract It is over sixty years since the first administration of human growth hormone (GH) to children with GH deficiency, and over thirty years since recombinant human GH has been available for treatment of GH deficiency and a wider range of non-GH deficiency disorders. From a diagnostic perspective, genetic analysis, using single gene or Sanger sequencing and more recently next generation or whole exome sequencing, has brought advances in the diagnosis of specific causes of short stature, which has enabled therapy to be targeted more accura...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Autoimmune thyroid diseases (AITDs), including Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), tend to aggregate with other non-thyroidal autoimmune diseases (NTADs). Aim of this Mini-review is to report the most recent insights concerning the clustering of NTADs in pediatric patients with either HT or GD, the pathophysiology of AITDs and the metamorphic thyroid autoimmunity. A systematic literature research of the last fifteen years, according to EQUATOR statement, was carried out through MEDLINE via PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) Embase, CINAHL, Cochrane Library, based on the following ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
PMID: 31306630 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Publication date: Available online 9 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Joshua D. Chew, Kevin D. Hill, Marshall L. Jacobs, Jeffrey P. Jacobs, Stacy A.S. Killen, Justin Godown, Amelia S. Wallace, Dylan Thibault, Karen Chiswell, David P. Bichell, Jonathan H. SoslowAbstractBackgroundTurner syndrome (TS) is a genetic syndrome characterized by monosomy X (45XO) in phenotypic females and is commonly associated with congenital heart disease. We sought to describe the distribution, mortality, and morbidity of congenital heart surgery in TS and compare outcomes to subjects without genetic syndromes.MethodsThe...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This study...
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research article Source Type: research
Publication date: Available online 9 July 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Dr Rashi Kalra, Dr Melissa Cameron, Catharyn SternAbstractDisorders of sex development (DSD) are a group of complex conditions that can affect chromosomal, gonadal, and/or phenotypical sex with a highly variable fertility potential amongst affected individuals. In this review we discuss fertility issues facing patients affected by DSD and Turner syndrome and summarise the literature on fertility and reproductive outcomes. We will also discuss fertility preservation prior to gonadotoxic treatmen...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Abstract BACKGROUND: Turner syndrome (TS) is a genetic syndrome characterized by monosomy X (45XO) in phenotypic females and is commonly associated with congenital heart disease. We sought to describe the distribution, mortality, and morbidity of congenital heart surgery in TS and compare outcomes to subjects without genetic syndromes. METHODS: The Society of Thoracic Surgeons Congenital Heart Surgery Database was used to evaluate index cardiovascular operations performed from 2000-2017 in pediatric patients (0-18 years) with and without TS. Analyses were stratified by most common operations, including coarct...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
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