Cognitive functioning following long-term cannabidiol use in adults with treatment-resistant epilepsy

We examined long-term cognitive effects of CBD in adults with TRE as part of an ongoing prospective, open-label safety study. Twenty-seven adults with TRE (mean age: 34[standard deviation (SD) + 14], female 52%) enrolled in the UAB CBD program completed standardized cognitive testing (NIH Toolbox Cognition Battery (NIHTB-CB)) at pre-CBD administration baseline and at one-year follow-up. Participants were receiving stable CBD dose at the time of one-year testing (mean = 36.5 mg/kg/day). The NIHTB-CB consisted of two global composite scales (Fluid and Crystallized) and seven individual tests measuring aspects of working memory, episodic memory, executive function, processing speed, and language. All participants had recorded Chalfont Seizure Severity Scale (CSSS) scores at each visit. Statistical analyses included t-test, Pearson correlation coefficient, and multivariate one-way ANOVA. At baseline, cognitive test performance was below average for both global composite scales (Fluid: 71 [± 18] range: 46–117) and Crystallized (76 [± 15] range: 59–112)]. Longitudinal analysis revealed no significant group change across the two global composite scales. Of the seven individual cognitive tests, none changed significantly over time. No correlation was found between the cognitive change scores and CBD dose (all P's ≥; 0.2). Change in cognitive test performance was not associated change in seizure severity rating. These findings are ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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ConclusionUnderstanding the influence of socio-cultural factors surrounding school enrollment of children with epilepsy could enhance public awareness campaigns about epilepsy and to improve school integration of these children.
Source: Seizure - Category: Neurology Source Type: research
Description Duke's designation as a Level 4 Epilepsy Center by the National Association of Epilepsy Centers contributes to Duke University Hospital being nationally ranked in neurology and neurosurgery being ranked #1 in North Carolina. Treatment TermsEpilepsy Evaluation and Diagnosis Is Default
Source: Duke Health News - Category: Consumer Health News Authors: Source Type: news
 In this episode of Inside Schizophrenia, our hosts tackle the topic of early onset – or childhood – schizophrenia. Host Rachel Star discusses her personal experiences with schizophrenia symptoms as an adolescent and Dr. Joseph Gonzalez-Heydrich from Harvard Medical School discusses some of the latest research. Listen in now! About Our Guest Joseph Gonzalez-Heydrich, MD is Director of the Developmental Neuropsychiatry Clinic at Boston Children’s Hospital and an Associate Professor of Psychiatry at the Harvard Medical School. He did his undergraduate and medical school at Johns Hopkins, his residency t...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Disorders Inside Schizophrenia Psychiatry Source Type: blogs
Authors: Tu W, Qian S Abstract Epilepsy is a common chronic disease of the central nervous system that can last for years or even decades, causing serious adverse effects on the body, mind, and psychology of patients. Traditional antiepileptic drugs can effectively control seizures, but because of large individual differences, serious adverse reactions, narrow therapeutic window and other shortcomings, more effective, new treatment drugs are looked for. Streptocaulon griffithii is a plant of Asclepiadaceae. 16-O-acetyldigitoxigenin (ACE) is a strong cardiac glycoside isolated from methanol extract of Streptocaulon ...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Authors: Chiou HH, Hsieh LP PMID: 31304570 [PubMed - in process]
Source: Acta Neurologica Taiwanica - Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Publication date: Available online 15 July 2019Source: NeuroscienceAuthor(s): Fabio Gualtieri, Marta Nowakowska, Eva-Lotta von Rüden, Isabel Seiffert, Heidrun PotschkaAbstractTemporal lobe epilepsy is triggered by an initial insult, such as status epilepticus, that initiates the process of epilepsy development. Heat shock protein 70 (Hsp70) is a ubiquitously expressed molecular chaperone, involved in the inflammatory response that is upregulated after status epilepticus. Hsp70 has been described as an endogenous intracellular ligand of Toll-like receptor 4. It is released from damaged or necrotic tissue and by activat...
Source: Neuroscience - Category: Neuroscience Source Type: research
The evolution of EEG/MEG source connectivity is both, a promising and controversial advance in the characterization of epileptic brain activity. In this narrative review we elucidate the potential of this technology to provide an intuitive view of the epileptic network at its origin, the different brain regions involved in the epilepsy, without the limitation of electrodes at the scalp level. Several studies have confirmed the added value of using source connectivity to localize the seizure onset zone and irritative zone or to quantify the propagation of epileptic activity over time. It has been shown in pilot studies that...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Patients with Alzheimer disease experience epileptic seizures up to 6.5 times more often than their cognitively normal peers, and often without the knowledge of their physician, new research suggests.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
Conditions:   Epilepsy in Children;   Mindfulness;   Quality of Life Intervention:   Behavioral: Making Mindfulness Matter (M3) Sponsors:   Lawson Health Research Institute;   Canadian Institutes of Health Research (CIHR) Not yet recruiting
Source: - Category: Research Source Type: clinical trials
A known cause of seizure-induced respiratory arrest is the deficiency in serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan. A recent study revealed a reduction in TPH2 protein expression in the brainstems of DBA/1 mice that developed recurrent seizure-induced respiratory arrest, whereas the activity of this protein was unexplored. Thus this study aims to investigate the association between intrinsic 5-hydroxytryptamine synthesis in the brainstem and the susceptibility for sudden ...
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
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