Effect of vascular endothelial growth factor and its receptors in adult otitis media with effusion

ConclusionsVEGF and its receptors function to induce the production of middle-ear effusions (MEEs) at acute stage of OME rather than chronic or recurrent stage, which is mainly mediated by HIF-1 α pathway. The formation of mucoid effusions is associated with MUC5B and VEGFR2, but not with duration and recurrence of OME.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research