Effect of the interleukin 10 polymorphisms on interleukin 10 production and visceral hypersensitivity in Chinese patients with diarrhea-predominant irritable bowel syndrome.

CONCLUSIONS: IL-10 rs1800896 C allele is correlated with higher IL-10 levels in the plasma and the PBMC culture supernatant, which is associated with a higher pain threshold in the Chinese patients with IBS-D. This study provides an explicit relationship of IL-10 polymorphisms with IL-10 production, which might help in understanding the pathogenesis of IBS-D.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0. PMID: 31205078 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research

Related Links:

Pain makes us human. It is a bell, fine-tuned by evolution, that often rings in moments necessary for our survival. Because of pain, we can receive warnings that trigger the reflexes to escape potential danger. But what happens when that bell continues to ring? How do we respond to a signal when it interferes with the other elements that make us human? Pain that lasts longer than six months is considered chronic, and it may not go away. With chronic pain, the bell’s ongoing signal gets your nervous system wound up and increases its reactivity to incoming messages. This can be quite distressing and anxiety-provoking. ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Mind body medicine Pain Management Source Type: blogs
You're reading 5 Surprising Things Stress Can Do to Your Body, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. You just got off a terrible meeting, your boss gave you an impossible deadline for the next project, your team is pushing you to make extra hours, and you still need to pick up the kids at school. Your body is in a “fight or flight response.” Your stress levels are high, you feel your breath get quicker and even feel your heart beating faster than usual. Although this is all a natural response from y...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement stress Source Type: blogs
This systematic review summarises evidence assessing endogenous pain inhibition in people with irritable bowel syndrome (IBS) compared with healthy controls using conditioned pain modulation (CPM) and offset analgesia (OA). Evidence regarding the role of psychological variables is also examined. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Four electronic databases were searched to retrieve studies assessing CPM or OA in adults diagnosed with IBS according to the ROME II/III criteria. Standardized mean differences were calculated for each stud...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research
By just engaging in the basic strategies in the Wheat Belly Total Health, Wheat Belly 10-Day Grain Detox, or Undoctored programs, many mild cases of small intestinal bacterial overgrowth, SIBO, reverse. These efforts thereby restore your ability to ingest prebiotic fibers without diarrhea, bloating, gas, abdominal discomfort, joint pain, and dark emotional feelings. Many people thereby are relieved of irritable bowel syndrome symptoms, fibromyalgia, or restless leg syndrome, or have greater power in reversing autoimmune conditions such as rheumatoid arthritis. Unfortunately, not everybody enjoys reversal of SIBO with our b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO grain-free probiotic undoctored wheat belly Source Type: blogs
This article presents the rationale for EAET, describes its principles and techniques, reviews its development and early testing as well as recent clinical trials, and critically analyzes the evidence base.Recent FindingsFour initial trials (between 2006 and 2011) demonstrated the efficacy of earlier versions of EAET. Four recent randomized, controlled trials of different EAET durations (1 to 8 sessions) and formats (individual or group) in patients with fibromyalgia, irritable bowel syndrome, pelvic pain, or medically unexplained symptoms support the earlier findings. EAET reliably reduces pain and interference, although ...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
During the 20th century, medicine became very good at compartmentalizing different systems of the body in order to understand them better. However, today we are increasingly realizing that different systems of the body are interconnected and cannot be completely understood in isolation. The brain-gut connection is one very important example of this phenomenon. Anatomy of the brain-gut connection What exactly is the connection between brain and gut? The brain sends signals to the digestive, or gastrointestinal (GI), tract via the sympathetic (“fight or flight”) nervous system and the parasympathetic (“rest...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Digestive Disorders Health Mind body medicine Pain Management Source Type: blogs
Conclusion It is clear that clinically, there is still much to be learnt about alexithymia and its relationship with a range of related phenomena. Firstly, is alexithymia a continuous and stable trait independent of psychological or somatic symptomology that is developed during childhood? Or is it instead a reactive state induced by trauma and distress at any age, which serves to defend against intense and upsetting emotions? This impacts on treatment options. For example, should we be focussing on early childhood interventions which target the child's emotional environment and parenting to encourage emotional exp...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionOne fourth of AGE patients developed PI-IBS after 6  months. Factors influencing its development were younger age, long duration of AGE, and abdominal pain. The PI-IBS risk score had good predictive accuracy in our population.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
When you hear the word meditation, you may think of sitting cross-legged with your eyes closed—breathing deeply and trying to clear your mind. While it’s true that meditation often involves quiet and focused contemplation, the whole “empty your mind” thing is a misconception, says Dr. Judson Brewer, director of research and innovation at Brown University’s Mindfulness Center. “Meditation is not about emptying our minds or stopping our thoughts, which is impossible,” Brewer says. “It’s about changing our relationships to our thoughts.” Doing so may help some stress...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Mental Health/Psychology Source Type: news
More News: Anxiety | China Health | Depression | Gastroenterology | General Medicine | Genetics | Irritable Bowel Syndrome | Pain | Psychology | Study