Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study

Publication date: Available online 17 June 2019Source: The Lancet PsychiatryAuthor(s): Chris Hollis, Qi Chen, Zheng Chang, Patrick D Quinn, Alexander Viktorin, Paul Lichtenstein, Brian D'Onofrio, Mikael Landén, Henrik LarssonSummaryBackgroundThere is a clinical concern that prescribing methylphenidate, the most common pharmacological treatment for attention-deficit hyperactivity disorder (ADHD), might increase the risk of psychotic events, particularly in young people with a history of psychosis. We aimed to determine whether the risk of psychotic events increases immediately after initiation of methylphenidate treatment or, in the longer term, 1 year after treatment initiation in adolescents and young adults with and without a previously diagnosed psychotic disorder.MethodsIn this cohort study, we used population-based observational data from the Swedish Prescribed Drug Register, the National Patient Register, and the Total Population Register, three population-based registers containing data on all individuals in Sweden, to attain data on sex, birth, death, migration, medication use, and psychotic events for all eligible participants. We screened individuals on these registers to identify those receiving methylphenidate treatment, and who were aged 12–30 years at the start of treatment, for their inclusion in the study. We used a within-individual design to compare the incidence of psychotic events in these individuals during the 12-week periods immediately bef...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research

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The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT) ensures the phasic nature of the DA signal, which underlies the ability of DA to encode reward prediction error, thereby driving motivation, attention, and behavioral learning. Disruptions to the DA system are implicated in a number of neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD) and, more recently, autism spectrum disorder (ASD). An ASD-associated de novo mutation in the SLC6A3 gene resulting in a threonine-to-methionine substitution at site 356 (DAT T356M) was recently identified and has been show...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Condition:   ADHD Intervention:   Drug: Amphetamine Extended Release (ER) Tablet 20 mg Sponsors:   Tris Pharma, Inc.;   Massachusetts General Hospital;   Massachusetts Institute of Technology Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Furuhashi Y Abstract Sleep-related eating disorder (SRED) is characterized by recurrent episodes of eating during the night, accompanied by partial consciousness and followed by limited recall. Zolpidem is a sedative-hypnotic drug commonly used to treat sleep disorders. Zolpidem reduces sleep latency and increases the total time of sleep. Here, we described a case of a patient with attention-deficit/hyperactivity disorder (ADHD) who suffered from zolpidem-induced SRED. The symptoms disappeared when the use of zolpidem as discontinuation. To the best of our knowledge, this is the first documented case of SR...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
MONDAY, July 22, 2019 -- Social-emotional and behavioral skills are important for school readiness, and preschoolers with attention-deficit/hyperactivity disorder (ADHD) have increased odds of impaired school readiness, according to a technical...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(Stanford Medicine) Preschoolers with symptoms of attention-deficit hyperactivity disorder are much less likely than other children their age to be ready for school, new research from the Stanford University School of Medicine has found.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
In conclusion, children with ADHD and residual behavioral problems after routine treatment may benefit from home-based behavioral parent training.
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Behavioral comorbidity is the rule rather than the exception in autism spectrum disorder (ASD), and the co-occurrence of autistic traits with subclinical manifestations of other psychiatric syndromes (e.g. anxiety, developmental coordination disorder) extends to the general population, where there is strong evidence for overlap in the respective genetic causes. An ASD “comorbidity” can have several fundamentally-distinct causal origins: it can arise due to shared genetic risk between ASD and non-ASD phenotypes (e.g., ASD and microcephaly in the context of the MECP2 mutation), as a “secondary symptom&rdquo...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: In Context Source Type: research
The ability to start and delay a task differs significantly between kids with attention deficit-hyperactivity disorder and typically developing children, new research suggests.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
ConclusionsThis study suggests that prenatal stress may be associated with ASD and ADHD; however, several limitations in the reviewed literature should be noted including significant heterogeneity and there is a need for carefully controlled future studies in this area.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
I have found that a rowboat provides an analogy that may help parents better understand the different types of learning and behavior problems. Different types of learning problems may present in similar ways, but they are different and need to be treated with different approaches. I typically start by helping the parents or guardians imagine the child is out in the middle of a lake, in a rowboat, going around in circles. We are on the shore trying to figure out what is going on.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: In My Opinion Source Type: research
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