Spinal cord stimulation in the treatment of neuropathic pain in chronic inflammatory demyelinating polyneuropathy

We describe a case of a 70-year old man with sensorimotor chronic inflammatory demyelinating polyneuropathy (CIDP) with small-fibre involvement resulting in severe diffuse neuropathic pain which was refractory to immunotherapy and anti-neuropathic medication. His pain was successfully treated with implantation of a spinal cord stimulation (SCS) system comprising bilateral cervical and lumbar epidural leads. Following SCS programming, he experienced a 50% reduction in average pain severity with substantial improvement in quality of life, persisting at 18 months after surgery. SCS has been employed to treat a variety of neuropathic pain syndromes. However, this is the first report to our knowledge of SCS utilised effectively for pain in CIDP. This therapy should be considered in painful CIDP for neuropathic pain refractory to medical management, though further studies are required to evaluate its efficacy.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research

Related Links:

Conclusions: In healthy Indians ≥50 years, ZOSTAVAX was well tolerated and resulted in expected VZV-specific antibody titer levels at 6 weeks post-vaccination. PMID: 31325263 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: Botulinum toxin significantly decreases the severity of pain in PHN patients and last for 4-6 month of the period. This decrease is less prominent by passing time. PMID: 31325262 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Amy B. Scher’s “This Is How I Save My Life” is the true story of a fiery young woman diagnosed with late-stage, chronic Lyme disease whose journey takes her from near-death in California to a trip around the world in search of her ultimate salvation. This excerpt coincides with the book’s release in paperback from Gallery Books, an imprint CBS sister company Simon &Schuster. I am twenty-eight years old when I arrive in magnificent India. I am here with my parents, an updated vaccine record, and a visa, searching for something I cannot find at home: a cure. In a tiny hospital on the outskirts of ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Simon and Schuster Source Type: news
Discussionby Dr MGK Murthy, Dr GA PrasadChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is characterized clinically by a progressive or relapsing course of many months to years of symptoms similar to compressive myelopathy.Etiology Remains unknown, but T-cell activation in nerves plays an important role in the pathogenesis of CIDP&antigens in Schwann cells have been identified.PathologicallyCIDP is characterized by mononuclear cell infiltrates, edema, segmental demyelination, and remyelination&“onion bulb formation” which describes enlarged fascicles with increased endoneural connectiv...
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs
CONCLUSION: Studies aimed at understanding the mechanisms underlying EAE-induced neuropathic pain and investigating the efficacy of novel pharmacological interventions at the animal level offer an exciting area of future research, and may inform future therapeutic options for MS-associated neuropathic pain. PMID: 28875858 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research
Conclusions:Breast cancer rarely metastasizes to the PNS and follows an indolent course, mimicking a chronic inflammatory neuropathy. Our cases were hormone-receptor positive, a possible risk factor.Disclosure: Dr. Vuppala has nothing to disclose. Dr. Lakraj has nothing to disclose. Dr. Barkhaus has nothing to disclose. Dr. Collins has received personal compensation for activities with Medpace as a consultant.
Source: Neurology - Category: Neurology Authors: Tags: Neuro-oncology: Brain and CNS Metastases Source Type: research
Conclusions:There was no report describing CIDP related to leprosy reverse reaction in the literature. This case could be attributed to cell injury caused by type 1reaction that exposed the neural antigens and incited an autoimmune reaction.Disclosure: Dr. Andrade has nothing to disclose. Dr. Vital has nothing to disclose. Dr. Pitta has nothing to disclose. Dr. Silveira has nothing to disclose. Dr. Giesel has nothing to disclose. Dr. Olmo has nothing to disclose. Dr. Sarno has nothing to disclose. Dr. Jardim has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
i S Abstract A 71-year-old woman presented with severe back pain, limb weakness and cranial nerve dysfunction associated with high cerebrospinal fluid (CSF) protein; we diagnosed Guillain-Barré syndrome and her symptoms completely resolved after intravenous immunoglobulin. Over the next 4 years, she had three further episodes of excruciating back pain accompanied by raised CSF protein, but without weakness, sensory loss, or abnormalities in routine nerve conduction studies. Sensory evoked potentials suggested proximal demyelination and lumbosacral plexus imaging suggested inflammation. We argue that this ...
Source: Practical Neurology - Category: Neurology Authors: Tags: Pract Neurol Source Type: research
Stiff person syndrome (SPS) is a chronic, progressive neurological disorder characterized by painful muscle spasms and rigidity with high titres of circulating anti-GAD antibodies. Intravenous immunoglobulin (IVIg) has been proven to be very effective in reducing the symptoms associated with SPS, most notably stiffness. Patients report being able to walk for the first time in months or even years and partake in activities of daily living including showering and household chores. A reduction in falls is also noted in patients receiving IVIg. Most patients report a drastically improved quality of life after receiving IVIg wi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Neuromuscular disease, Pain (neurology), Spinal cord Thur 21, Parallel session 5: Therapeutics Source Type: research
People with celiac disease are more than twice as likely to suffer from nerve damage than the general population, according to a recently published study in the medical journal JAMA Neurology. The association is so strong that the study authors suggest people with nerve damage should also be screened for celiac disorder in order to pinpoint potential treatment options, according to lead researcher Jonas Ludvigsson of the Swedish medical university Karolinska Institutet. "The current guidelines suggest that patients with neuropathy [nerve pain] should be screened for type 1 diabetes and certain vitamin deficiencies,...
Source: Science - The Huffington Post - Category: Science Source Type: news
More News: Back Pain | Brain | Chronic Pain | CIDP | Fibre | Immunotherapy | Neurology | Neuroscience | Neurosurgery | Pain | Pain Management | Study