Transdermal delivery of fluvastatin loaded nanoemulsion gel: Preparation, characterization and in vivo anti-osteoporosis activity.

The objective of present study was to develop hydrogel based nanoemulsion (NE) drug delivery system for transdermal delivery and evaluate its potential in in vivo anti-osteoporotic activity. NE was prepared using aqueous phase titration method and characterized for droplet size, zeta potential and morphology. It was then formulated into hydrogel based NE gel using carbopol 940 as gelling agent. NE gel was evaluated for pH, viscosity, in vitro/ex vivo permeation studies and in vivo anti-osteoporotic activity. The results indicated formation of spherical, nano sized globules of NE ranging from 11.17 ± 0.24 to 128.8 ± 0.16 nm with polydispersity of
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research

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Condition:   Osteoporosis Intervention:   Diagnostic Test: CT Sponsors:   St. Louis Joint Replacement Institute;   Lima Corporation Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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Source: - Category: Research Source Type: clinical trials
ABSTRACTThe risk of osteoporosis is increased in rheumatoid arthritis (RA). Anti-tumor necrosis factor (TNF) therapy has markedly improved the outcomes of RA patients but does not improve osteoporosis in some reports. This could be a combined result of disease severity and other therapeutic agents, such as glucocorticoids that accelerate osteoporosis progression. We evaluated the effects of anti-TNF therapy on osteoporosis in an animal model of RA and explored the possible mechanisms involved. Six-week-old TNF transgenic (TNF-Tg) mice with early stage erosive arthritis were treated with TNF antibody (Ab) or control immunog...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Along with worldwide population aging, diabetes mellitus and its complications have become important public health issues that are associated with increases in mortality, morbidity, and healthcare costs [1]. Multiple studies have shown that men and women with diabetes have an increased risk of fracture at any anatomical site [2], resulting in the consensus that osteoporosis and its related bone fractures comprise a complication of diabetes [3]. Fractures, especially fragility fractures, decrease the patient ’s quality of life, increase healthcare costs, and increase the mortality risk in patients with diabetes [3,4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Oper Orthop Traumatol. 2021 Oct 18. doi: 10.1007/s00064-021-00738-3. Online ahead of print.ABSTRACTOBJECTIVE: Pain reduction and improvement in quality of life with sacroiliac joint (SIJ) fusion.INDICATIONS: Chronic SIJ-associated pain; positive response to SIJ injection with local anesthetic; positive SIJ provocation tests; failed conservative therapy over 6 months.CONTRAINDICATIONS: Non-SIJ-associated pain; tumor/infection/unstable fracture in the implantation area; malformations; tumor or osteolysis of the sacrum or ilium bone; active infection at the implantation site; allergy to metal components; secondary gain from i...
Source: Operative Orthopadie und Traumatologie - Category: Orthopaedics Authors: Source Type: research
J Family Med Prim Care. 2021 Aug;10(8):3089-3093. doi: 10.4103/jfmpc.jfmpc_386_21. Epub 2021 Aug 27.ABSTRACTBACKGROUND: Osteoporosis is a growing public health issue that is prevalent among the Saudi Arabian population. Several risk factors for the disease have been identified and could be modified using preventive strategies, including increasing awareness about the disease in susceptible individuals.METHODS: A cross-sectional study was conducted using interview-based questionnaires to evaluate knowledge of osteoporosis risk factors in a sample of 513 Saudi participants attending primary health care centers (PHCCs) in the...
Source: Primary Care - Category: Primary Care Authors: Source Type: research
CONCLUSION: The number of parity and prolonged period of lactation have a negative effect on BMD in both regions especially in the lower socioeconomic strata with poor nutritional intake. Our data supports that parity and duration of lactation can be associated with future osteoporosis.PMID:34660421 | PMC:PMC8483082 | DOI:10.4103/jfmpc.jfmpc_2349_20
Source: Primary Care - Category: Primary Care Authors: Source Type: research
ABSTRACTOsteoporosis is a systemic skeletal disease characterized by low bone mass and bone structural deterioration that may result in fragility fractures. Use of bone imaging modalities to accurately predict fragility fractures is always an important issue, yet the current gold standard of dual-energy X-ray absorptiometry (DXA) for diagnosis of osteoporosis cannot fully satisfy this purpose. The latest high-resolution peripheral quantitative computed tomography (HR-pQCT) is a three-dimensional (3D) imaging device to measure not only volumetric bone density, but also the bone microarchitecture in a noninvasive manner that...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
This Teachable Moment describes the lack of appropriate treatment for osteoporosis after a patient ’s initial fragility fracture, which unnecessarily increases the common, costly, and morbid risks of refracture.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice. To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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