Mediastinal Rosai-Dorfman Disease with Widespread Lesions. When Surgical Biopsy is Needed.

Mediastinal Rosai-Dorfman Disease with Widespread Lesions. When Surgical Biopsy is Needed. Ann Thorac Surg. 2019 Jun 14;: Authors: Furia S, Nannini N, Pascarella A, Breda C Abstract Rosai-Dorfman disease (RDD) is a rare benign disorder of the histiocytes, affecting lymph-nodes in its classical form. Extranodal RDD is considered the uncommon subtype and potentially impairs all tissues as well as intrathoracic organs. In our report, a FDG-PET scan of a mediastinal mass infiltrating the lungs and of widespread lesions suggested the presence of a metastatic disease. Open thoracic biopsy was required for immunochemistry and histopathology. Mediastinal mass with lesions disseminated throughout the body is an unusual presentation of extranodal RDD that calls for a challenging differential diagnosis to rule out the suspicion of metastatic malignancy. PMID: 31207246 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research