Chromosomal aberrations in pregnancy and fetal loss: Insight on the effect of consanguinity, review of 1625 cases

This study is a review of 1625 product of abortion and fetal tissue using Array comparative genomic hybridization in combination with QF ‐PCR. This is the second largest study with the main difference 35 percent of couples are related. We found a statistically significant difference between copy number variations and aneuploidies found in related versus unrelated couples. AbstractBackgroundPregnancy loss affects 10% –15% of pregnancies and is caused by several factors, maternal and fetal. Most common cause is chromosomal aneuploidy and has traditionally been detected by karyotyping product of conception and/or fetal tissue. In recent years, array comparative genomic hybridization (a‐CGH) has been used becau se of its higher detection and lower failure rates.MethodsDNA was extracted from 1625 products of abortion or fetal tissue. In 1,104 cases both quantitative fluorescent ‐polymerase chain reaction (QF‐PCR) and a‐CGH, and in 521 cases only a‐CGH, was performed.ResultsThe detection rate using QF ‐PCR and a‐CGH is 20% compared to 12.7%, overall, and 15.7%, excluding failed samples, by karyotypes in our center. QF‐PCR and a‐CGH failed in 1.9% of cases, while the failure rate for karyotypes was 20.1%. The difference of detection and failure rates is significant (p‐value 
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Publication date: Available online 16 July 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Kai-Lun Hu, Hongcui Zhao, Yang Yu, Rong LiAbstractKisspeptins are a family of neuropeptides that are critical for the puberty initiation and female fertility. Plasma or serum kisspeptin is mainly derived from the placenta during pregnancy and plasma kisspeptin levels significantly increase across pregnancy. Plasma kisspeptin levels could be used as a potential biomarker for the detection of miscarriage, pre-eclampsia, gestational trophoblastic neoplasia (GTN), and fetal development. Kissp...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
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Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Sara De Carolis, Francesco Cianci, Gelsomina Del Sordo, Serafina Garofalo, Cristina Garufi, Antonio Lanzone, Angelo Zoli, Elisa Gremese
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Condition:   Dengue Dengue Fever Dengue Hemorrhagic Fever Intervention:   Drug: CYD-TDV Dengue Vaccine Sponsor:   Sanofi Pasteur, a Sanofi Company Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Evidence published in the Cochrane Library provides strong evidence thatfinancial incentives helped people to stop smoking and stay stopped long term.The team investigated whether rewards such as cash payments, vouchers, or the return of money deposited by those taking part, worked. The review summarizes the results from 33 randomised controlled trials involving more than 21,600 people from eight countries. They included ten trials that focused on pregnant smokers who were rewarded with vouchers for quitting and staying smoke free.The review was led by University of East Anglia (UK) and involved researchers from the Univer...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
[Ghanaian Times] Bolgatanga -The Upper East Regional Population Officer, Mr Alosibah Akare Azam, has observed that adherence to Family Planning (FP), which is central to gender equality and women empowerment, could lead to poverty reduction and improved living standards of the people.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
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Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
Authors: Tan H, Hu S, Qiongyu , Chen Y, Jin L, Wu C Abstract The fertility success rates of clinical and laboratory-assisted reproductive techniques (ART) remain low, despite major advances. The aim of this study was to conduct a systematic literature review and assess whether the intrauterine administration of human chorionic gonadotropin (hCG) before embryo transfer (ET) improved the clinical outcomes of sub-fertile women undergoing assisted reproduction. The electronic databases PUBMED, EMBASE and Web of Science were systematically searched for randomized controlled trials (RCTs) published from inception to June...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
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