Lidocaine Gel Eases Mammogram Pain, Needle...

Lidocaine (Xylocaine) and Topicaine gels are local anesthetics. Researchers have shown that this kind of anesthetic can ease the pain of a mammogram procedure. It can also lessen the pain of a needle stick, and other pains related to cancer therapies. Read more to learn some uses of Lidocaine (Xylocaine) and Topicaine.
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: health Source Type: news

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In this study we used FGFR1 and FGFR2 gene amplifications containing human MFM223 breast cancer cells in an experimental xenograft model of breast cancer bone growth using intratibial inoculation technique. This model mimics bone metastases in breast cancer patients. The effects of an FGFR inhibitor, dovitinib dilactic acid (TKI258) on tumor growth and tumor-induced bone changes were evaluated. Cancer-induced bone lesions were smaller in dovitinib-treated mice as evaluated by X-ray imaging. Peripheral quantitative computed tomography imaging showed higher total and cortical bone mineral content and cortical bone mineral de...
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Conclusions The anti-Notch3 ADC PF-06650808 has demonstrated a manageable safety profile and early signs of antitumor activity in patients with advanced BC.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Authors: Vieira C, Fragoso M, Pereira D, Medeiros R Abstract The accomplishment of successful pain treatment requires evaluation, characterization and quantification. The present study characterized pain and survival in a cohort of patients with cancer with bone metastasis who were treated with intravenous bisphosphonates. A total of 84 patients self-completed the Brief Pain Inventory (BPI) and 36-Item Short Form Survey (SF-36), between November 2010 and March 2011 with a 5-year survival follow-up as a surrogate marker of cancer burden. The median age was 62 years old (34-85), 64% of patients were female and 58% of...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Abstract With declining mortality rates, the number of breast cancer survivors is increasing. Ongoing care after breast cancer treatment is often provided by primary care physicians. This care includes surveillance for cancer recurrence with a history and physical examination every three to six months for the first three years after treatment, every six to 12 months for two more years, and annually thereafter. Mammography is performed annually. Magnetic resonance imaging of the breast is not indicated unless patients are at high risk of recurrence, such as having a hereditary cancer syndrome. Many breast cancer su...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Opinion statementBisphosphonates are utilized routinely in breast cancer. In metastatic disease with bone involvement, bisphosphonates prevent or delay skeletal-related events and can improve pain control. Different agents have shown benefit compared with placebo or no treatment. While in unselected patients, comparison between zoledronic acid and pamidronate did not show a significant difference, exploratory analyses showed that in patients with osteolytic lesions or hypercalcemia, zoledronic acid is superior to pamidronate. De-escalating treatment with zoledronic acid from every 4 to every 12  weeks has been shown t...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
A 79-year-old woman with a history of anxiety, depression, and chronic obstructive pulmonary disease, as well as a remote history of breast cancer treated with lumpectomy and radiation, presented to her primary care physician with new right upper  quadrant abdominal pain. Abdominal ultrasound identified 3 liver lesions, with MRI confirmation. Computed tomography–guided liver biopsy identified a diagnosis of small cell carcinoma, positive for synaptophysin and chromogranin. Positron emission tomography/computed tomography identified a 3.3- cm left hilar mass with mediastinal lymphadenopathy and concern for lympha...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
ConclusionsCompounds 1–10, 12 and 14–15 were isolated for the first time from the P. heterophylla. This result enriches the previous studies on the chemical constituents of P. heterophylla. Compounds 1 and 15 were reported for the first time have cytotoxic activities against tumor cells. Compounds 1, 5, 6, 7, 12, 15 showed cytotoxic activities against tumor cells. This result reveals that the active ingredient of P. heterophylla are composed of phenylpropanoids, iridoid and coumarin. This study provides some theoretical basis for the anti-tumor research of P. heterophylla.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, breast cancer patients encounter a broad range of information about BRT prior to their radiation oncology consultation, which may contribute to worry and misconceptions. Potentially rare and serious side effects were considered important to address.
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
san G Abstract Severe and poorly treated pain often accompanies breast cancer. Thus, novel mechanisms involved in breast cancer-induced pain should be investigated. Then, it is necessary to characterize animal models that are reliable with the symptoms and progression of the disease as observed in humans. Explaining cancer-induced nociception in a murine model of breast carcinoma was the aim of this study. 4T1 (104) lineage cells were inoculated in the right fourth mammary fat pad of female BALB/c mice; after this, mechanical and cold allodynia, or mouse grimace scale (MGS) were observed for 30 days. To determine ...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
Conditions:   Breast Cancer;   Joint Pain Interventions:   Dietary Supplement: Curcumin;   Other: Placebo Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Recruiting
Source: - Category: Research Source Type: clinical trials
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