The combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia

British Journal of Cancer, Published online: 18 June 2019; doi:10.1038/s41416-019-0502-xThe combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research

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Publication date: Available online 16 July 2019Source: The Lancet HaematologyAuthor(s): Anne-Sophie Michallet, Marie-Sarah Dilhuydy, Fabien Subtil, Valerie Rouille, Beatrice Mahe, Kamel Laribi, Bruno Villemagne, Gilles Salles, Olivier Tournilhac, Alain Delmer, Christelle Portois, Brigitte Pegourie, Veronique Leblond, Cecile Tomowiak, Sophie de Guibert, Frederique Orsini, Anne Banos, Philippe Carassou, Guillaume Cartron, Luc Mathieu ForneckerSummaryBackgroundIn patients with chronic lymphocytic leukaemia, achievement of a complete response with minimal residual disease of less than 0·01% (ie,
Source: The Lancet Haematology - Category: Hematology Source Type: research
AbstractApoptosis, the process of programmed cell death, occurs normally during development and aging. Members of the B-cell lymphoma 2 (BCL2) family of proteins are central regulators of apoptosis, and resistance to apoptosis is one of the hallmarks of cancer. Targeting the apoptotic pathway via BCL2 inhibitors has been considered a promising treatment strategy in the past decade. Initial efforts with small molecule BH3 mimetics such as ABT-737 and ABT-263 (navitoclax) pioneered the development of the first-in-class Food and Drug Administration (FDA)-approved oral BCL2 inhibitor, venetoclax. Venetoclax was approved for th...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Contributor : Shimin ShuaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite an intensive search for non-coding cancer drivers, only a few have been discovered to date and none have been found among the RNAs contributing to the spliceosome. Here we report a highly recurrent A>C somatic mutation at the third base of U1 spliceosomal RNA in several tumour types. This mutation changes the preferential A-U base-pairing between U1 and 5 ′ splice site to C-G base-pairing, thereby creating novel splice junctions and altering the splice pattern of multiple genes, including those ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
We present a comprehensive mechanism detailing the structural and protein dynamics components of the allosteric coupling between nucleotide-induced tetramerization and the catalysis of dNTP hydrolysis by SAMHD1. PMID: 31296733 [PubMed - as supplied by publisher]
Source: Biochemical Society Transactions - Category: Biochemistry Authors: Tags: Biochem Soc Trans Source Type: research
Chronic lymphocytic leukemia is a malignancy with good prognosis. However, the incidence of secondary tumors increases every year after the diagnosis of chronic lymphotcytic leukemia. One of the induced second...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
We describe the Continuous Individualized Risk Index (CIRI), a method to dynamically determine outcome probabilities for individual patients utilizing risk predictors acquired over time. Similar to “win probability” models in other fields, CIRI provides a real-time probability by integrating risk assessments throughout a patient’s course. Applying CIRI to patients with diffuse large B cell lymphoma, we demonstrate improved outcome prediction compared to conventional risk models. We demonstrate CIRI’s broader utility in analogous models of chronic lymphocytic leukemia and breast adenocarcinoma and pe...
Source: Cell - Category: Cytology Source Type: research
borg Palma In lymphomas of B-cell origin, cancer cells orchestrate an inflammatory microenvironment of immune and stromal cells that sustain the tumor cell survival and growth, known as a tumor microenvironment (TME). The features of the TME differ between the different lymphoma types, ranging from extremely inflammatory, such as in Hodgkin lymphoma, to anergic, leading to immune deficiency and susceptibility to infections, such as in chronic lymphocytic leukemia. Understanding the characteristic features of the TME as well as the interactions between cancer and TME cells has given insight into the pathogenesis of m...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Hamadani M, Ganguly S, Bacher V, Lazarus H, Reshef R, Hildebrandt GC, Inamoto Y, Cahn JY, Solh M, Kharfan-Dabaja MA, Ghosh N, Saad A, Aljurf M, Schouten HC, Hill BT, Pawarode A, Kindwall-Keller T, Saba NS, Copelan E, Nathan S, Beitinjaneh AM, Savani B, Cerny J, Grunwald MR, Yared J, Wirk B, Nishihori T, Chhabra S, Olsson R, Bashey A, Gergis U, Popat U, Sobecks RM, Alyea EP, Saber W, Brown JR Abstract PURPOSE: To develop a prognostic model and cytogenetic risk classification for previously treated patients with chronic lymphocytic leukemia (CLL) undergoing reduced intensity conditioning (RIC) allogeneic hematopoiet...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Lori A. Leslie, MD, Hematologist-Oncologist, Lymphoma Department, John Theurer Cancer Center, Hackensack Meridian Health shares details on the CLL14 trial in chronic lymphocytic leukemia (CLL) that wa... Author: obr Added: 06/27/2019
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Cancers, Vol. 11, Pages 896: Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12 Cancers doi: 10.3390/cancers11070896 Authors: Autore Strati Innocenti Corrente Trentin Cortelezzi Visco Coscia Cuneo Gozzetti Mauro Frustaci Gentile Morabito Molica Falcucci D’Arena Murru Vincelli Efremov Ferretti Rigolin Vitale Tisi Reda Visentin Sica Foà Ferrajoli Laurenti Chronic Lymphocytic Leukemia (CLL) patients with +12 have been reporte...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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