Johns Hopkins Children's Center among country's top-ranked pediatric hospitals

Johns Hopkins Children's Center has been ranked as the best pediatric hospital in the state, and once again as one of the 10 best in the country, according to U.S. News&World Report. The annual Best Children’s Hospitals rankings are intended to help families of children with complex and rare conditions find the best medical care. The rankings highlight the top 50 hospital centers in 10 pediatric specialties: cancer, cardiology and heart surgery, diabetes and endocrinology, g astroenterology and…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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DiscussionWe estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Introduction: Life expectancy in women with breast cancer (BC) is 80% at 5 years. Age, medications, obesity, metabolic syndrome and diabetes increase cardiovascular risk. The Mediterranean diet (MeD) and low glycemic index (GI) diets, nevertheless, are protective. Therefore, we evaluated the effect of low-GI Mediterranean diet on cardiovascular risk factors in women treated for BC.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Introduction: Several lines of evidence confirm the role of the Mediterranean Diet (MedD) on primary and secondary prevention of chronic disease, such as diabetes, cardiovascular disease and cancer. Health-Related Quality of Life (HRQOL) includes physical, mental, emotional and social factors. A few studies evaluated the impact of the MedD on HRQOL. Therefore, we investigated the possible effect of adherence to the MedD on HRQOL in the DEDiCa Study (NCT02786875) participants, a study that evaluates the combined effect of diet, physical activity and vitamin D on the risk of recurrence in women diagnosed with breast cancer.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
AbstractBackgroundImmune checkpoint inhibitors, single or in combination, have recently become a cornerstone for the treatment of many malignancies. Ipilimumab, a CTLA-4 inhibitor, was initially FDA approved for treatment of unresectable or metastatic melanoma and subsequently in combination therapy for other cancers. Ipilimumab-induced hypophysitis (IH) risk of development varies in different studies between 0 and 17%. Furthermore, little is known on how to predict which patients will develop IH and its impact on efficacy of Ipilimumab and survival for these patients. Here we reviewed IH and its impact on progression-free...
Source: Pituitary - Category: Endocrinology Source Type: research
Healthy employees are productive employees. And their oral health is strongly connected to their overall health — so don’t overlook the importance of dental benefits. According to the Academy of General Dentistry, regular dental visits can help identify early signs of 120 diseases, including heart disease, diabetes, and several forms of cancer. In fact, 90 percent of systemic diseases have symptoms in and around the mouth. Dental benefits are a key factor in ensuring that we take care of our…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Abstract A significant obstacle to the study of human cancer biology and the testing of human specific immunotherapeutics is the paucity of translational models that recapitulate both the growth of human tumors and the functionality of human immune systems. Humanized mice engrafted with human hematopoietic stem cells (HSC) and patient-derived xenografts (PDX) enable preclinical investigation of the interactions between the human immune system and human cancer. We use immunodeficient non-obese diabetic (NOD, scid, gamma) NSG™ or NSG™-SGM3 mice as hosts for establishment of human immunity following HSC i...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Contributors : Wan Y Yang ; Pei S Rao ; Yong C Luo ; Hua K Lin ; Sing H Huang ; Jinn M Yang ; Chiou H YuhSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPrevious studies have identified liver cancer associated to NASH, diabetes, obesity, and some genetic risk factors. We want to investigate the synergism between diet and genetic risk factors in hepatocarcinogenesis using omics data of four background zebrafish in three types of diet. We found the fishes have more genetic risk factors at the same time, and have higher probability to accelerate cancer formation. Overfed and high fat diet...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Contributors : Wan Y Yang ; Pei S Rao ; Yong C Luo ; Hua K Lin ; Sing H Huang ; Jinn M Yang ; Chiou H YuhSeries Type : Expression profiling by arrayOrganism : Danio rerioPrevious studies have identified liver cancer associated to NASH, diabetes, obesity, and some genetic risk factors. We want to investigate the synergism between diet and genetic risk factors in hepatocarcinogenesis using omics data of four background zebrafish in three types of diet. We found the fishes have more genetic risk factors at the same time, and have higher probability to accelerate cancer formation. Overfed and high fat diet will increase the ch...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Danio rerio Source Type: research
Publication date: Available online 17 July 2019Source: Neuroscience LettersAuthor(s): Anamaria Falcão Pereira, Lus Mário Silva Pereira, Cristiane Maria Pereira Silva, Bruno Wesley Freitas Alves, Jéssica Sales Barbosa, Francisco Maxwell Martins Pinto, Ana Carolina Pereira, Karla Oliveira Silva, Renata Bessa Pontes, Nylane Maria Nunes Alencar, Roberto César Pereira Lima-Júnior, Mariana Lima ValeAbstractOxaliplatin is a third-generation platinum drug commonly used as the first line treatment of metastatic colorectal cancer. Oxaliplatin-based anticancer regimens course with dose-limiting neur...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 17 July 2019Source: Neuroscience LettersAuthor(s): Alagudurai Krishnamoorthy, Murugan Sevanan, Sugumar Mani, Mangayarkarasi Balu, Sravani Balaji, Ramajayan PAbstractParkinson disease occurs due to the depletion of dopaminergic neurons in brain resulting in decreased dopamine level and abnormal protein aggregation. Chrysin is a flavonoid which possesses pharmacological properties against various diseases like hypertension, diabetes, cancer, etc. According to the recent literatures, it is evidenced that chrysin protects mice against Focal Cerebral Ischemia/Reperfusion Injury. The present st...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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