Cortisol and IgA are Involved in the Progression of Alzheimer's Disease. A Pilot Study.

Cortisol and IgA are Involved in the Progression of Alzheimer's Disease. A Pilot Study. Cell Mol Neurobiol. 2019 Jun 15;: Authors: de la Rubia Ortí JE, Prado-Gascó V, Sancho Castillo S, Julián-Rochina M, Romero Gómez FJ, García-Pardo MP Abstract It is known that stress and immune systems are related with Alzheimer's disease (AD). However, the relationship of both systems in the progression of disease is not clearly demonstrated. Hair cortisol and salivary immunoglobulin A (IgA) were quantified in 49 patients with mild, moderate, and severe AD. A significant change was seen in both molecules as AD progressed from mild to moderate and severe. Low levels of cortisol were observed in mild AD patients compared with moderate and severe. However, IgA showed a contrary pattern. High levels were observed in mild AD patientes but low in moderate and severe AD subjects. The secretion of cortisol and IgA seems to be very different at the start compared with posterior development of AD suggesting that neuroinflammation can be involved. Both molecules could be used as possible therapeutical tools. PMID: 31203531 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research