LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction

Long noncoding RNAs (lncRNAs) are a class of novel molecular regulators in cardiac development and diseases. However, the role of specific lncRNAs in cardiac fibrosis remains to be fully explored. The aim of the present study was to investigate the effects and underlying mechanisms of lncRNA PCFL (pro-cardiac fibrotic lncRNA) on cardiac fibrosis after myocardial infarction (MI).Cardiac fibroblasts (CFs) with gain and loss of function of PCFL and mice with global knockout or overexpression of PCFL were used to explore the effects of PCFL on cardiac fibrosis.

Source: Journal of Molecular and Cellular Cardiology - June 16, 2019 Category: Cytology Authors: Fei Sun, Yuting Zhuang, Haixia Zhu, Hao Wu, Danyang Li, Linfeng Zhan, Wanqi Yang, Yin Yuan, Yilin Xie, Shuang Yang, Shenjian Luo, Wenmei Jiang, Jifan Zhang, Zhenwei Pan, Yanjie Lu Source Type: research