Alteration in ventricular pressure stimulates cardiac repair and remodeling

The mammalian heart undergoes complex structural and functional remodeling to compensate for stresses such as pressure overload. While studies suggest that, at best, the adult mammalian heart is capable of very limited regeneration arising from the proliferation of existing cardiomyocytes, how myocardial stress affects endogenous cardiac regeneration or repair is unknown. To define the relationship between left ventricular afterload and cardiac repair, we induced left ventricle pressure overload in adult mice by constriction of the ascending aorta (AAC).

Source: Journal of Molecular and Cellular Cardiology - June 16, 2019 Category: Cytology Authors: Kazumasa Unno, Angelos Oikonomopoulos, Yusuke Fujikawa, Yusuke Okuno, Singo Narita, Tomohiro Kato, Ryo Hayashida, Kazuhisa Kondo, Rei Shibata, Toyoaki Murohara, Yanfei Yang, Seema Dangwal, Konstantina-Ioanna Sereti, Qiu Yiling, Kory Johnson, Alokkumar Jha Source Type: research