GSE113638 AGO-iCLIP-seq analysis of Zika infected neural stem cells

Contributors : Jason Dang ; Tariq RanaSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAGO-iCLIP-seq was utilized to characterize the RNAs bound to AGO in human neural stem cells infected with Zika virus strains Paraiba at MOI 1. miRNAs and mRNAs were analyzed to determine changes in RNAs loaded into the RISC 4 days post-infection.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research

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by Murilo Sena Amaral, Ernesto Goulart, Luiz Carlos Caires-J únior, David Abraham Morales-Vicente, Alessandra Soares-Schanoski, Roselane Paiva Gomes, Giovanna Gonçalves de Oliveira Olberg, Renato Mancini Astray, Jorge E. Kalil, Mayana Zatz, Sergio Verjovski-Almeida Zika virus (ZIKV) causes congenital Zika syndrome (CZS), which is characterized by fetal demise, microcephaly and other abnormalities. ZIKV in the pregnant woman circulation must cross the placental barrier that includes fetal endothelial cells and trophoblasts, in order to reach the fetus. CZS oc curs in ~1–40% of cases of pregnant women in...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
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Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
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Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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Source: Cell Stem Cell - Category: Stem Cells Authors: Tags: Cell Stem Cell Source Type: research
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Source: Cell Reports - Category: Cytology Source Type: research
(University of California - San Diego) Two different UC San Diego research teams identified the same molecule --αvβ5 integrin -- as Zika virus' key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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