GSE132880 Single cell RNA-seq of adult mouse heart endothelial transcriptomes following myocardial infarction
Contributors : Ziwen Li ; Marco Meloni ; Richard S Tylor ; Ross Dobie ; Beth E Henderson ; Mairi BrittanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA better understanding of the pathways that regulate regeneration of the coronary vasculature is of fundamental importance for the advancement of strategies to treat patients with heart disease. By analyzing single cell transcriptome of resident cardiac endothelial cells (ECs) in adult mouse hearts under both healthy and myocardial infarction (MI) settings, we provide molecular definitions of murine cardiac endothelial heterogeneity and characterizations of pro-angiogenic resident ECs.
In conclusion, e-noise is a potential danger in our world, and further studies are needed of its effects on mechanisms of aging, disease, and human health.
Abstract Ventricular remodeling (VR) is a complex pathological process of cardiomyocyte apoptosis, cardiac hypertrophy, and myocardial fibrosis, which is often caused by various cardiovascular diseases(CVDs) such as hypertension, acute myocardial infarction, heart failure(HF), etc.. It is also an independent risk factor for a variety of CVDs, which will eventually to damage the heart function, promote cardiovascular events, and lead to an increase in mortality. MicroRNAs (miRNAs) can participate in a variety of CVDs through post-transcriptional regulation of target gene proteins. Among them, microRNA-30 (miR-30) i...
HEART ATTACK can strike suddenly and the consequences can be fatal. Lifestyle factors can raise the risk of developing heart disease and having a heart attack. Evidence suggests it could be linked to a common condition.
AbstractCardiovascular disease (CVD) is emerging as a major threat to healthy aging among people with HIV (PHIV). PHIV face heightened risks for coronary heart disease (CHD)/myocardial infarction (MI) and heart failure (HF), fueled by systemic immune activation and by metabolic dysregulation. Women with HIV (WHIV) evidence unique patterns of vascular and myocardial pathology as compared to men with HIV (MHIV). These patterns include a predilection to microvascular dysfunction and type II MI, as well as a penchant for diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF). Investigations are underw...
People who ate fried foods one to three times a week had a 7% higher risk of heart attack and stroke compared to those who ate fried foods less than once a week. For those who ate fried foods daily, the risk jumped to 14% higher.
HEART attacks or coronary heart disease is a major cause of death both in the UK and worldwide. Spotting symptoms are crucial for protecting yourself from developing a heart attack. What are the two unusual signs that mean you might be at risk?
Coronary heart disease (CHD) is a major cause of death worldwide . It is characterized by cholesterol-containing deposits in the major heart blood vessels, which results in angina, shortness of breath, fatigue and myocardial infarction . The number of survivors is growing due to an aging population, and advancement in CHD treatment and management [3,4]. Most of the research on survivorship has focused on morbidity and mortality, however there is increasing awareness that quality of life (QoL) is also an important health indicator [5,6].
Conclusion: Reduced salt intake, omega-3 LC-PUFA use, and folate supplementation could reduce risk for some cardiovascular outcomes in adults. Combined calcium plus vitamin D might increase risk for stroke. Primary Funding Source: None. PMID: 31284304 [PubMed - as supplied by publisher]
Trimethylamine N-oxide (TMAO), a gut microbe-derived metabolite of dietary choline and other trimethylamine-containing nutrients, has been associated with poor prognosis in coronary heart disease. However, the role and underlying mechanisms of TMAO in the cardiac fibrosis after myocardial infarction (MI) remains unclear.
Researchers at the University of Bristol have developed a way to make stem cells move toward heart tissue when they are injected intravenously. The treatment could improve the efficacy of stem cell therapies for heart disease, which are currently ham...