Acute, genetic and sub-chronic toxicities of flaxseed derived Maillard reaction products.

Acute, genetic and sub-chronic toxicities of flaxseed derived Maillard reaction products. Food Chem Toxicol. 2019 Jun 13;:110580 Authors: Wei CK, Ni ZJ, Thakur K, Liao AM, Hu F, Huang JH, Wei ZJ Abstract In present study, the acute, genetic, and sub-chronic toxicities of flaxseed derived Maillard reaction products (MRPs) were investigated. Acute toxicity results showed that the 50% lethal dose (LD50) of MRPs in rats was >15.0 g/kg body weight (BW); whereas, the 50% effective dose (ED50) of MRPs was 12.3 g/kg BW. Ames test demonstrated that the back-mutation colonies for MRPs addition of 5,000 μg/dish was positive, which displayed certain mutagenicity. There were no significant differences in micronucleus rate and sperm deformity rate among different dose groups. The sub-chronic toxicity confirmed that less than 0.75 gMRPs/kg BW intake did not affect weight, food intake, mortality, gross pathology, histology, hematology, and serum biochemistry. The obtained results can provide an imperative reference on the safety of a meat flavoring agents. PMID: 31202938 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research